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Cardiovascular Research 2000 45(2):330-338; doi:10.1016/S0008-6363(99)00274-6
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice

Xiao-Ming Gao, Anthony M Dart, Elizabeth Dewar, Garry Jennings and Xiao-Jun Du*

Experimental Cardiology Laboratory and Alfred Baker Medical Unit, Baker Medical Research Institute and the Alfred Hospital, Melbourne, Victoria, Australia

* Corresponding author. Tel.: +61-3-9522-4399; fax: +61-3-9521-1362 xiaojun.du{at}baker.edu.au

Objective: To test the usage of serial echocardiography in mice with induced myocardial infarct (MI) and to characterize the mouse model of MI. Methods: C57 mice underwent open-chest surgery to induce left coronary artery occlusion or sham-operation (SH). Echocardiography was performed before and at 1, 2.5, 6 and 9 weeks after surgery. Left ventricular end diastolic and end systolic dimensions (LVEDd, LVESd) and fractional shortening (FS) were measured. Haemodynamics was determined at week 9 by LV catheterization and hearts were examined morphologically. Results: Post-infarct mortality was 46% (10/22), of which, 70% died of acute heart failure or LV rupture within the first week. LV dimensions and FS remained stable in SH group (n=10) during the study period. In surviving MI mice (n=12), there was modest LV dilatation and fall in FS at week 1. Compared with week 0 values, there were progressive increase in LVEDd (+50~+66%) and LVESd (+124~+171%), and decline in FS (–53~–73%) during the 2.5~9 week period. Infarcted mice also had lower LV systolic pressure (LVSP), dP/dtmax and dP/dtmin (all P<0.01 vs. SH group). Infarct size, LVSP and dP/dt significantly correlated with FS and LV dimensions (r=0.61~0.80, all P<0.01). Conclusions: LV remodeling and dysfunction in mice with MI are time-dependent processes and early remodeling seems associated with high risk of rupture and acute pump failure. Our findings provide a baseline description of this murine model and confirm echocardiography as a reliable means to serially assess changes of cardiac structure and function after MI.

KEYWORDS Heart failure; Infarction; Remodeling; Ultrasound; Ventricular function


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