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Cardiovascular Research 2000 45(1):231-237; doi:10.1016/S0008-6363(99)00335-1
© 2000 by European Society of Cardiology
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Copyright © 2000, European Society of Cardiology

Mouse electrocardiography

An interval of thirty years

Xander H.T. Wehrens, Susanne Kirchhoff and Pieter A. Doevendans*

Department of Molecular Cardiology, Academic Hospital Maastricht, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands

* Corresponding author. Tel.: +31-43-387-5095; fax: +31-43-387-5104 pieter.doevendans{at}cardio.azm.nl

The interest in mouse electrophysiology is expanding fast, despite the marked differences between mouse and man. Different methods have become available to analyse the electrical activity in the mouse heart in vivo. The mouse genome can be altered with relative ease, which allows the molecular dissection of the various components that contribute to de- and repolarisation of the cardiomyocyte and the initiation and propagation of cardiac arrhythmias. Mouse ischaemia reperfusion models have been used recently to study preventive measures against ischaemic myocyte damage. In the present review, the electrophysiological measurements performed in mice to date are discussed and complemented with results from a mouse ischaemia reperfusion model.

KEYWORDS ECG; Heart rate (variability)


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