© 2000 by European Society of Cardiology
Copyright © 2000, European Society of Cardiology
The normal range and determinants of the intrinsic heart rate in man*
Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 9, P.O. Box 22700, 1105 AZ Amsterdam, The Netherlands
* Tel.: +31-20-566-3265; fax: +31-20-697-5458 t.opthof{at}amc.uva.nl
Jose and Collison published a study on the normal range and the determinants of intrinsic heart rate in man in Cardiovascular Research in 1970 [Jose AD, Collison D. The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res 1970; 4: 160–167)]. The intrinsic heart rate is the heart rate under complete pharmacological blockade. They showed that (i) the resting heart rate is lower than the intrinsic heart rate and that (ii) the intrinsic heart rate declines with age. They also established that the variability in intrinsic heart rate between individuals of the same age is of the same order as the effect of ageing at the population level. This update discusses the relevance of these data with emphasis on sinus node function and autonomic balance. The paper of Jose and Collison was cited more than 200 times. The frequency of citation started to increase more than 10 years after publication.
KEYWORDS Aging; Autonomic nervous system; Gender; Heart rate (variability); Sinus node
* An update of the original paper by Jose AD and Collison D: (Cardiovasc Res 1970;4:160–167)
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Dhein Cx30 in the sinus node of murine heart: just one connexin more, or more? Evidence for a construction principle? Cardiovasc Res, November 14, 2009; (2009) cvp351v2. [Full Text] [PDF]
|
|
|
|
|
|
D. Gros, M. Theveniau-Ruissy, M. Bernard, T. Calmels, F. Kober, G. Sohl, K. Willecke, J. Nargeot, H. J. Jongsma, and M. E. Mangoni Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate Cardiovasc Res, September 4, 2009; (2009) cvp280v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Mangoni and J. Nargeot Genesis and Regulation of the Heart Automaticity Physiol Rev, July 1, 2008; 88(3): 919 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Baruscotti and R. B. Robinson Electrophysiology and pacemaker function of the developing sinoatrial node Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2613 - H2623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, Y. Zhao, M. Lei, H. Dobrzynski, J. H. Liu, A. V. Holden, and M. R. Boyett Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H165 - H174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A Jones, M. K Lancaster, and M. R Boyett Ageing-related changes of connexins and conduction within the sinoatrial node J. Physiol., October 15, 2004; 560(2): 429 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Conrath and T. Opthof {beta}3-Adrenoceptors in the heart Cardiovasc Res, December 1, 2002; 56(3): 353 - 356. [Full Text] [PDF]
|
|
|
|
|
|
T. Opthof Function and structure of the mouse sinus node: nothing you can see that isn't shown Cardiovasc Res, October 1, 2001; 52(1): 1 - 4. [Full Text] [PDF]
|
|
|
|
|
|
M.R. Boyett, H. Honjo, and I. Kodama The sinoatrial node, a heterogeneous pacemaker structure Cardiovasc Res, September 1, 2000; 47(4): 658 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Opthof, R. Coronel, H. M. E. Rademaker, J. T. Vermeulen, F. J. G. Wilms-Schopman, and M. J. Janse Changes in Sinus Node Function in a Rabbit Model of Heart Failure With Ventricular Arrhythmias and Sudden Death Circulation, June 27, 2000; 101(25): 2975 - 2980. [Abstract] [Full Text] [PDF]
|
|