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Cardiovascular Research 1999 44(3):615-622; doi:10.1016/S0008-6363(99)00257-6
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Chronic cardiac denervation affects the speed of coronary vascular regulation

Isabelle Vergroesena,*, Daphne Merkusa, Jurgen W.G.E van Teeffelena, Jenny Dankelmana, Jos A.E Spaana, Harry B van Wezelb, Mark I.M Noblec and Angela J Drake-Hollandc

aDepartment of Medical Physics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
bDepartment of Anaesthesiology, University of Amsterdam, Amsterdam, The Netherlands
cNational Heart and Lung Institute, Imperial College of Science Technology and Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK

* Corresponding author. Tel.: +31-20-566-4994; fax: +31-20-691-7233 I.Vergroesen{at}amc.uva.nl

Objective: We tested the hypothesis that the rate of adaptation of coronary metabolic vasodilatation and autoregulation is modulated by the cardiac nerves. Methods: Anaesthetised dogs (seven innervated (control) and seven with denervated hearts) were subjected to controlled pressure perfusion of the left main coronary artery. Heart rate was controlled by pacing. Results: The steady state autoregulation curves and metabolic regulation curves were similar in the two groups. A sudden increase or decrease in heart rate was associated with a faster response (22% shorter half-times) in the innervated than the denervated dogs (P<0.001). A sudden increase or decrease in coronary arterial perfusion pressure was associated with a slower response (24% longer half-times) in the innervated than the denervated hearts (P<0.005). Conclusions: We conclude that the speed of response to metabolic and perfusion pressure changes is partly mediated by cardio-cardiac reflexes. Reflex coronary vasodilatation appears to reinforce the metabolic vasodilatation of a heart rate increase and oppose the vasoconstriction in response to increased perfusion pressure.

KEYWORDS Coronary circulation; Innervation; Regional blood flow; Vasoconstriction/dilation


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