© 1999 by European Society of Cardiology
Copyright © 1999, European Society of Cardiology
Is there a local renin—angiotensin system in the heart?
aCardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, 3015 GE Rotterdam, The Netherlands
bCardiovascular Research Institute COEUR, Department of Internal Medicine I, Erasmus University Rotterdam, 3015 GE Rotterdam, The Netherlands
* Corresponding author. Tel.: +31-10-408-7540; fax: +31-10-408-9458 danser{at}farma.fgg.eur.nl
The existence of a local renin—angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated.
KEYWORDS Angiotensin; ACE inhibitors; Interstitial space; Myocytes; Renin angiotensin system
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