Is there a local renin--angiotensin system in the heart?

doi:10.1016/S0008-6363(99)00202-3

Cardiovascular Research 1999 44(2):252-265; doi:10.1016/S0008-6363(99)00202-3
© 1999 by European Society of Cardiology

This Article

	Full Text
	FREE Full Text (PDF)
	E-letters: Submit a response
	Alert me when this article is cited
	Alert me when E-letters are posted
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Personal Archive
	Download to citation manager
	Request Permissions
	Disclaimer

Google Scholar

	Articles by Danser, A.H.J.
	Articles by van Kats, J. P
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Danser, A.H.J.
	Articles by van Kats, J. P

Social Bookmarking

	What's this?

Is there a local renin—angiotensin system in the heart?

A.H.Jan Danser^a^,*, Jasper J Saris^a^,b, Martin P Schuijt^a^,b and Jorge P van Kats^b

^aCardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, 3015 GE Rotterdam, The Netherlands
^bCardiovascular Research Institute COEUR, Department of Internal Medicine I, Erasmus University Rotterdam, 3015 GE Rotterdam, The Netherlands

^* Corresponding author. Tel.: +31-10-408-7540; fax: +31-10-408-9458 danser{at}farma.fgg.eur.nl

The existence of a local renin—angiotensin system in theheart is still a controversial issue. This review discussesthe evidence, obtained from studies in cardiac cells, in isolatedperfused hearts and in intact animals and humans, both undernormal and pathological conditions, for local production ofprorenin, renin, angiotensinogen, angiotensin-converting enzyme,angiotensin I and angiotensin II at cardiac tissue sites. Inaddition, the role of alternative angiotensin-generating enzymes(cathepsin, chymase) and the possibility of (pro)renin uptakefrom the circulation is evaluated.

KEYWORDS Angiotensin; ACE inhibitors; Interstitial space; Myocytes; Renin angiotensin system

Add to CiteULike CiteULike Add to Connotea Connotea Add to Del.icio.us Del.icio.us What's this?

This article has been cited by other articles:

K Akat, M Borggrefe, and J J Kaden
Aortic valve calcification: basic science to clinical practice
Heart, April 1, 2009; 95(8): 616 - 623.
[Abstract] [Full Text] [PDF]

P. M. Cummins
A new addition to the renin-angiotensin peptide family: proAngiotensin-12 (PA12)
Cardiovasc Res, April 1, 2009; 82(1): 7 - 8.
[Full Text] [PDF]

J. A. Jessup, A. J. Trask, M. C. Chappell, S. Nagata, J. Kato, K. Kitamura, and C. M. Ferrario
Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats
Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2614 - H2618.
[Abstract] [Full Text] [PDF]

P. J Lijnen, V. V Petrov, and R. H Fagard
Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2001; 2(2): 117 - 122.
[Abstract] [PDF]

R. Schulz and G. Heusch
Review: AT 1-receptor blockade in experimental myocardial ischaemia/reperfusion
Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S136 - S140.
[PDF]

C. Ruwhof and A. van der Laarse
Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways
Cardiovasc Res, July 1, 2000; 47(1): 23 - 37.
[Abstract] [Full Text] [PDF]

				P. M. Cummins A new addition to the renin-angiotensin peptide family: proAngiotensin-12 (PA12) Cardiovasc Res, April 1, 2009; 82(1): 7 - 8. [Full Text] [PDF]

				J. A. Jessup, A. J. Trask, M. C. Chappell, S. Nagata, J. Kato, K. Kitamura, and C. M. Ferrario Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2614 - H2618. [Abstract] [Full Text] [PDF]

				P. J Lijnen, V. V Petrov, and R. H Fagard Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors Journal of Renin-Angiotensin-Aldosterone System, June 1, 2001; 2(2): 117 - 122. [Abstract] [PDF]

				R. Schulz and G. Heusch Review: AT 1-receptor blockade in experimental myocardial ischaemia/reperfusion Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S136 - S140. [PDF]

				C. Ruwhof and A. van der Laarse Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways Cardiovasc Res, July 1, 2000; 47(1): 23 - 37. [Abstract] [Full Text] [PDF]