© 1999 by European Society of Cardiology
Copyright © 1999, European Society of Cardiology
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism in coronary disease and malignant ventricular arrhythmias
aDepartment of Cardiology, University of Vienna, Vienna, Austria
bDepartment of Nephrology, University of Vienna, Vienna, Austria
cDepartment of Computer Sciences, University of Vienna, Vienna, Austria
* Corresponding author. Corresponding address: University of Vienna, Department of Cardiology, Währinger Görtel 18-20, A-1090 Vienna, Austria. Tel.: +43-40-400-4614, ext. 4965; fax: +43-408-1148 AAnvari{at}mail.kard.akh-wien.ac.at
Objectives: It has been reported that patients carrying the angiotensin-converting enzyme (ACE) deletion DD genotype with the angiotensin II type 1 (AT1) C allele are at increased risk for myocardial infarction. The frequency distribution of the ACE and AT1 receptor gene polymorphism and their possible relation regarding malignant ventricular arrhythmias in patients with coronary artery disease (CAD) and left ventricular dysfunction was determined. Methods: The ACE I/D and AT1 A/C polymorphisms (using polymerase chain reaction) in 100 Caucasian patients suffering from CAD with a history of malignant ventricular arrhythmias treated with an implantable cardioverter defibrillator (ICD group) was compared to 127 age-matched Caucasian patients with CAD and no history of malignant ventricular arrhythmias (control group). All patients had reduced left ventricular ejection fraction of <40% and were comparable regarding sex distribution, body mass index, ACE-inhibitor treatment, lipid status and duration of CAD. Results: The prevalence of DD/CC in the ICD group was significantly higher (19% versus 10%, p<0.0001). The risk for malignant ventricular arrhythmias was associated with the combination of ACE D and AT1 C alleles (odds-ratio: 2.4, 95% confidence interval 1.41 to 3.94, p<0.001). The distribution of ACE and AT1 genotypes was not different between the two group. Conclusions: Patients with coronary artery disease and left ventricular dysfunction carrying ACE D and AT1 C alleles are at increased risk for development of malignant ventricular arrhythmias. Because of available pharmacological inhibitors, these results may have clinical implications for the prevention of sudden cardiac death.
KEYWORDS Arrhythmia; Coronary disease; Renin angiotensin system; Angiotensin; Receptor-polymorphism
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Ozben, I. Altun, V. Sabri Hancer, A. K. Bilge, A. M. Tanrikulu, R. Diz-Kucukkaya, A. S. Fak, E. Yilmaz, and K. Adalet Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk? Journal of Renin-Angiotensin-Aldosterone System, December 1, 2008; 9(4): 215 - 220. [Abstract] [PDF]
|
|
|
|
|
|
C. Sekuri, F S. Cam, E. Ercan, I. Tengiz, A. Sagcan, E. Eser, A. Berdeli, and M. Akin Renin-angiotensin system gene polymorphisms and premature coronary heart disease Journal of Renin-Angiotensin-Aldosterone System, March 1, 2005; 6(1): 38 - 42. [Abstract] [PDF]
|
|
|
|
 |
|
 G. F. Tomaselli and D. P. Zipes What Causes Sudden Death in Heart Failure? Circ. Res., October 15, 2004; 95(8): 754 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Apfalter, M. R. Hammerschlag, J. Boman, J. Wojta, K. Huber, and I. Huk Reliability of Nested PCR for the Detection of Chlamydia pneumoniae in Carotid Artery Atherosclerosis Stroke, July 1, 2003; 34 (7): e73 - e75. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Firouzi and W. A. Groenewegen Gene polymorphisms and cardiac arrhythmias Europace, January 1, 2003; 5(3): 235 - 242. [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Khalil, A. W. Basher, E. J. Brown Jr, and I. A. Alhaddad A remarkable medical story: benefits of angiotensin-converting enzyme inhibitors in cardiac patients J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1757 - 1764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Jeron, C Hengstenberg, S Engel, H Lowel, G.A.J Riegger, H Schunkert, and S Holmer The D-allele of the ACE polymorphism is related to increased QT dispersion in 609 patients after myocardial infarction Eur. Heart J., April 2, 2001; 22(8): 663 - 668. [Abstract] [PDF]
|
|