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Cardiovascular Research 1999 43(3):731-738; doi:10.1016/S0008-6363(99)00113-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

L-Arginine and L-NAME have no effects on the reendothelialization process after arterial balloon injury

Isabelle Sixa, Eric Van Belleb, Régis Bordeta, Delphine Corseauxa, Jacques Callebertc, Bernard Dupuisa, Christophe Bautersb,* and Michel E. Bertrandb

aDepartment of Pharmacology, University of Lille, 59037 Lille Cedex, France
bDepartment of Cardiology, University of Lille, 59037 Lille Cedex, France
cDepartment of Biochemistry, Hôpital Lariboisière, 75010 Paris Cedex, France

* Corresponding author. Present address: Service de Cardiologie B, Hôpital Cardiologique, Boulevard du Professeur J. Leclercq, 59037 Lille Cedex, France. Tel.: +33-320-445302; fax:+33-320-535874 cbauters{at}chru-lille.fr

Objective: Growth regulatory properties of nitric oxide (NO) in cultured endothelial cells is controversial. The aim of our study was to investigate the effect of L-arginine, the endogenous NO precursor, and L-NAME, an inhibitor of NO synthase on the reendothelialization process after angioplasty. Methods: Fifty-five New Zealand White rabbits underwent denudation of the left iliac artery. After injury the rabbits were randomized in three groups: L-arginine 2.25% (L-arginine, n=19); NG-nitro-L-arginine methyl ester 15 mg/kg/day (L-NAME, n=19); and placebo (controls, n=17). Treatment was solubilized in drinking water. Reendothelialization was evaluated at 4 weeks by macroscopic evaluation of Evans blue staining and endothelial-specific immunostaining (CD-31) on cross sections. Intimal hyperplasia was evaluated by morphometric analysis. Results: Despite a significant increase in plasma arginine (P=0.001) and a reduction in intimal hyperplasia (P=0.003) with L-arginine, neither agent had a significant effect on reendothelialization at 4 weeks (controls=36±4%, L-arginine=43±3%, L-NAME=33±4%; NS). Conclusion: These results suggest that, in spite of previously demonstrated effects on neointimal hyperplasia, the NO pathway does not influence the regrowth of macrovascular endothelial cells in vivo.

KEYWORDS Experimental; Vasculature; Circulatory physiology arteries; Endothelial factors; Nitric oxide; Angioplasty


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