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Cardiovascular Research 1999 43(3):509-520; doi:10.1016/S0008-6363(99)00161-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Molecular control of nitric oxide synthases in the cardiovascular system

Andreas Papapetropoulos1, Radu Daniel Rudic and William C Sessa*

Department of Pharmacology, Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA

* Corresponding author. Tel.: +1-203-737-2291; fax: +1-203-737-2290. william.sessa{at}yale.edu

Nitric oxide plays an important role in cardiovascular homeostasis. In this review, the regulation of the three nitric oxide synthase isoforms in the cardiovascular system are examined at molecular and cellular levels. In addition, recent information gleaned from the use of NOS knockout mice are discussed.

KEYWORDS Nitric oxide synthases; Molecular control; Cardiovascular system

1 Present address: Laboratory for Molecular Pharmacology, University of Athens, Athens, Greece.


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