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Cardiovascular Research 1999 43(2):371-381; doi:10.1016/S0008-6363(99)00117-0
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Differential expression of {alpha}1, {alpha}3 and {alpha}5 integrin subunits in acute and chronic stages of myocardial infarction in rats

Jun Nawata, Isao Ohno, Shogen Isoyama, Jun Suzuki, Shoko Miura, Jun Ikeda and Kunio Shirato*

First Department of Internal Medicine, Tohoku University School of Medicine, Aoba-ku, 1-1 Seiyo-machi, Sendai 980-8574, Japan

* Corresponding author. Tel.: +81-22-717-7153; fax: +81-22-717-7156 nawata{at}int1.med.tohoku.ac.jp

Objective: Anchoring cardiac myocytes to extracellular matrix, which is mediated mainly by integrins on their surfaces, is important for maintaining the architecture of myocardial tissues and transmitting mechanical force. We evaluated the expression of {alpha} integrin subunits on myocytes and the accumulation of interstitial collagen and fibronectin at acute and chronic stages after myocardial infarction. Methods: Myocardial infarction was induced by ligation of left coronary arteries in rats. The expression of {alpha}1, {alpha}3 and {alpha}5 integrin subunits, and accumulation of collagen and fibronectin were analyzed with immunohistochemistry or sirius-red staining. Results: In hearts without infarction, moderate expression of the {alpha}3 subunit and only slight expression of the {alpha}5 subunit were observed on myocytes. In the first week after infarction, the {alpha}1 subunit, collagen and fibronectin were increased only in the peri-infarcted area, while the {alpha}5 subunit was increased both in peri-infarcted and non-infarcted areas. At day 42, the expression of the {alpha}1 subunit and collagen were still increased, although the {alpha}5 subunit and fibronectin were decreased. The expression of the {alpha}3 subunit was not altered throughout the experimental period. Conclusion: These data suggest that integrin subunits play an important role in healing and remodeling processes after myocardial infarction.

KEYWORDS Connective tissue; Infarction; Interstitial spaces


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