Skip Navigation

Cardiovascular Research 1999 43(2):371-381; doi:10.1016/S0008-6363(99)00117-0
© 1999 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Nawata, J.
Right arrow Articles by Shirato, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nawata, J.
Right arrow Articles by Shirato, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1999, European Society of Cardiology

Differential expression of {alpha}1, {alpha}3 and {alpha}5 integrin subunits in acute and chronic stages of myocardial infarction in rats

Jun Nawata, Isao Ohno, Shogen Isoyama, Jun Suzuki, Shoko Miura, Jun Ikeda and Kunio Shirato*

First Department of Internal Medicine, Tohoku University School of Medicine, Aoba-ku, 1-1 Seiyo-machi, Sendai 980-8574, Japan

* Corresponding author. Tel.: +81-22-717-7153; fax: +81-22-717-7156 nawata{at}int1.med.tohoku.ac.jp

Objective: Anchoring cardiac myocytes to extracellular matrix, which is mediated mainly by integrins on their surfaces, is important for maintaining the architecture of myocardial tissues and transmitting mechanical force. We evaluated the expression of {alpha} integrin subunits on myocytes and the accumulation of interstitial collagen and fibronectin at acute and chronic stages after myocardial infarction. Methods: Myocardial infarction was induced by ligation of left coronary arteries in rats. The expression of {alpha}1, {alpha}3 and {alpha}5 integrin subunits, and accumulation of collagen and fibronectin were analyzed with immunohistochemistry or sirius-red staining. Results: In hearts without infarction, moderate expression of the {alpha}3 subunit and only slight expression of the {alpha}5 subunit were observed on myocytes. In the first week after infarction, the {alpha}1 subunit, collagen and fibronectin were increased only in the peri-infarcted area, while the {alpha}5 subunit was increased both in peri-infarcted and non-infarcted areas. At day 42, the expression of the {alpha}1 subunit and collagen were still increased, although the {alpha}5 subunit and fibronectin were decreased. The expression of the {alpha}3 subunit was not altered throughout the experimental period. Conclusion: These data suggest that integrin subunits play an important role in healing and remodeling processes after myocardial infarction.

KEYWORDS Connective tissue; Infarction; Interstitial spaces


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Loufrani, K. Retailleau, A. Bocquet, O. Dumont, K. Danker, H. Louis, P. Lacolley, and D. Henrion
Key role of {alpha}1{beta}1-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries
Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1906 - H1913.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.