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Cardiovascular Research 1999 43(1):32-43; doi:10.1016/S0008-6363(99)00079-6
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Role of energy metabolism in the preconditioned heart – a possible contribution of mitochondria

Satoshi Takeo* and Yoshihisa Nasa

Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, 192-0392 Japan

* Corresponding author. Tel.: +81-426-76-4583; fax: +81-426-76-5560 takeos{at}ps.toyaku.ac.jp

A brief period of ischemia and reperfusion has been shown to protect the myocardium against subsequent sustained ischemia and reperfusion injury, which is called "preconditioning". A great number of investigators have explored the mechanisms underlying this preconditioning-induced cardioprotection. This article dealt with possible mechanisms of energy metabolism and mitochondrial activity for preconditioning-induced cardioprotection. Particularly, the contribution of energy metabolites produced during a brief period of ischemia and reperfusion injury, as well as mitochondrial function that is modified by changes in mitochondrial ATPase activity, opening of mitochondrial ATP-dependent potassium channels and production of free radicals in mitochondria, to ischemic preconditioning is discussed.

KEYWORDS Acidosis; Adenosine; Glycolytic flux; Ischemia; KATP channel; Mitochondria; Mitochondrial ATPase; Preconditioning


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