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Cardiovascular Research 1999 43(1):25-31; doi:10.1016/S0008-6363(99)00074-7
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

New look at myocardial infarction: toward a better aspirin

Richard J Bing*, Tadahiko Yamamoto, Masako Yamamoto, Rani Kakar and Anna Cohen

Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, CA, USA

* Corresponding author. Tel.: +1-626-397-5451; fax: +1-626-795-5774

The evidence for the formation of NO and of its oxidation products, as well as of prostacyclin and thromboxane by the infarcted heart muscle is reviewed. The importance of inflammatory cells, primarily macrophages of cardiac origin is documented. Because of its side effects on gastric mucosa and kidney by aspirin, several modifications of aspirin are currently being developed. These are based on eliminating their inflammatory effect by selective inhibition of COX-2, or by attaching an NO-delivering side chain to the aspirin molecule (NO–aspirin), or by combining two preparations, an NO donor with aspirin. NO–aspirins and the combination of an NO-donor with aspirin promise to be beneficial in the early stages of myocardial infarction. Unfortunately, the main beneficial effect of aspirin, that of inhibition of thrombus formation, is also the cause for its most dreaded complication, hemorrhagic stroke. None of the new aspirins is able to prevent this complication.

KEYWORDS Myocardial infarction; Nitric oxide; Prostaglandin; Aspirin; NO donor


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