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Cardiovascular Research 1999 42(3):670-679; doi:10.1016/S0008-6363(99)00007-3
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

The role of Bcl6 in mature cardiac myocytes

Takehiko Yoshidaa,e, Tetsuya Fukudaa,g, Masahiko Hatanoa, Haruhiko Kosekib, Shin-ichiro Okabea, Kazuki Ishibashia, Satoko Kojimaa, Masafumi Arimaa, Issei Komurof, Genichiro Ishiid, Tohru Mikig, Shinsaku Hirosawag, Nobuyuki Miyasakag, Masaru Taniguchic, Takenori Ochiaie, Kaichi Isonoe and Takeshi Tokuhisaa,*

aDepartment of Developmental Genetics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
bDepartment of Molecular Embryology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
cDepartment of Molecular Immunology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
dDepartment of Pathology,Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
eSecond Department of Surgery, Chiba University School of Medicine, Chiba 260-8670, Japan
fDepartment of Medicine III, The University of Tokyo School of Medicine, Tokyo 113, Japan
gFirst Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo 113, Japan

tokuhisa{at}med.m.chiba-u.ac.jp

* Corresponding author. Tel.: +81-43-226-2181; fax: +81-43-226-2183

Objective: The Bcl6 gene encodes a sequence-specific transcriptional repressor and is ubiquitously expressed in adult murine tissues including heart muscle. The objective of this study was to examine the role of Bcl6 in cardiac myocytes. Method: We developed Bcl6-deficient (Bcl6–/–) mice and histologically examined hearts from these mice. Results: Massive myocarditis with eosinophilic infiltration occurred in Bcl6–/– mice after 4–6 weeks of age. Since expression of the Bcl6 gene was induced in normal cardiac myocytes after 2 weeks of age and thereafter detected through adulthood, loss of Bcl6 in mature cardiac myocytes may be related to the induction of eosinophilic myocarditis. To examine the effects of eosinophils from Bcl6–/– mice on normal hearts, bone marrow cells from Bcl6–/– mice were adoptively transferred into sublethally irradiated RAG1-deficient mice. Although massive eosinophilic infiltration was detected in conjunctivas and spleens from the chimeric mice, myocarditis was never observed. Electron microscopic analysis of cardiac myocytes from Bcl6–/– mice revealed a spectrum of degenerative changes prior to eosinophilic infiltration. Conclusion: Bcl6 may not be essential for the maturation of cardiac myocytes but may play a role in protecting mature cardiac myocytes from eosinophilic inflammation.

KEYWORDS Bcl6; Knockout mice; Myocaditis; Terminal differentiation; Tissue eosinophilia


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