© 1999 by European Society of Cardiology
Copyright © 1999, European Society of Cardiology
Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release
Department of Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
dbers{at}luc.edu
* Corresponding author. Tel.: +1-708-216-1018; fax: +1-708-216-6308
There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR) membrane in cardiac myocytes. The relationship between channel structure, associated proteins and function of these Ca channels is discussed. The sarcolemmal Ca channels are crucial both to the basic cellular electrophysiological properties and control of cardiac contractility (via excitation–contraction coupling). The intracellular Ca release channels (or ryanodine receptors) respond to triggering events mediated by sarcolemmal ion currents and are largely responsible for releasing Ca which activates the myofilaments to produce contraction. Several possible mechanisms of excitation–contraction coupling are discussed. The Ca released from the SR can also feedback on several sarcolemmal ion currents and alter action potential configuration as well as contribute to arrhythmogenesis.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. I. Lee, M. G. Klein, W. Zhu, R.-P. Xiao, V. Gerzanich, and K. Y. Xu Activation of (Na++K+)-ATPase Modulates Cardiac L-Type Ca2+ Channel Function Mol. Pharmacol., April 1, 2009; 75(4): 774 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Catalucci, D.-H. Zhang, J. DeSantiago, F. Aimond, G. Barbara, J. Chemin, D. Bonci, E. Picht, F. Rusconi, N. D. Dalton, et al. Akt regulates L-type Ca2+ channel activity by modulating Cav{alpha}1 protein stability J. Cell Biol., March 23, 2009; 184(6): 923 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Jaleel, H. Nakayama, X. Chen, H. Kubo, S. MacDonnell, H. Zhang, R. Berretta, J. Robbins, L. Cribbs, J. D. Molkentin, et al. Ca2+ Influx Through T- and L-Type Ca2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes Circ. Res., November 7, 2008; 103(10): 1109 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Beauvois, A. Arredouani, J.-C. Jonas, J.-F. Rolland, F. Schuit, J.-C. Henquin, and P. Gilon Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic {beta}-cells J. Physiol., August 15, 2004; 559(1): 141 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Findlay Physiological modulation of inactivation in L-type Ca2+ channels: one switch J. Physiol., January 15, 2004; 554(2): 275 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Findlay {beta}-Adrenergic and muscarinic agonists modulate inactivation of L-type ca2+ channel currents in guinea-pig ventricular myocytes J. Physiol., December 1, 2002; 545(2): 375 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Viatchenko-Karpinski and S. Gyorke Modulation of the Ca2+-induced Ca2+ release cascade by {beta}-adrenergic stimulation in rat ventricular myocytes J. Physiol., June 15, 2001; 533(3): 837 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hajnoczky, G. Csordas, M. Madesh, and P. Pacher The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria J. Physiol., November 15, 2000; 529(1): 69 - 81. [Abstract] [Full Text] [PDF]
|
|