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Cardiovascular Research 1999 42(2):284-297; doi:10.1016/S0008-6363(99)00013-9
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Electrical remodeling in ischemia and infarction

Judith M.B Pinto and Penelope A Boyden*

Department of Pharmacology, Columbia College of Physicians and Surgeons, 630 West 168th St., New York, NY 10032, USA

* Corresponding author. Tel.: +1-212-305-7907; fax: +1-212-305-0529

This is a review of the electrophysiologic changes occurring at different times following myocardial infarction, both in the infarcted region (substrate) and in areas remote from the infarct. Regulators of channel function which might contribute to re-modeling, including autocrine/paracrine factors involved in ion channel gene regulation, are discussed.

KEYWORDS Purkinje; Ventricular; Myocytes; Myocardial infarction; Ion channels


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