Skip Navigation

Cardiovascular Research 1999 41(2):458-464; doi:10.1016/S0008-6363(98)00320-4
© 1999 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Smits, P. C
Right arrow Articles by Borst, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smits, P. C
Right arrow Articles by Borst, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1999, European Society of Cardiology

Angioscopic complex lesions are predominantly compensatory enlarged: an angioscopy and intracoronary ultrasound study

Pieter C Smitsa,b,1, Gerard Pasterkampa,b,2, Peter P.T de Jaegerea, Pim J de Feyterc and Cornelius Borsta,*

aDepartment of Cardiology, Heart Lung Institute, University Hospital Utrecht, Utrecht, Netherlands
bInteruniversity Cardiology Institute of the Netherlands, Utrecht, Netherlands
cHeart Center Rotterdam, Erasmus University Rotterdam, Rotterdam, Netherlands

* Corresponding author. Tel.: +31-30-250-7155; fax: +31-30-252-2693; e-mail: exp.card@hli.azu.nl

Objectives: Atherosclerotic remodeling of the coronary artery may lead to compensatory enlargement or to shrinkage. Post-mortem data suggest a relation between compensatory enlargement and histopathological markers of plaque vulnerability. In patients that required a coronary intervention, we investigated retrospectively the relation between the angioscopic appearance and the remodeling mode of the culprit lesion. Methods: In 34 patients, coronary angioscopy and intracoronary ultrasound (ICUS) imaging was performed across the culprit lesion before the intervention. Only single de novo lesions were included. With angioscopy, lesions with a smooth surface without thrombus were classified as smooth, whereas lesions with an irregular surface with or without thrombus were classified as complex. With ICUS, remodeling of the culprit lesions was determined by the relative cross-sectional vessel area (lesion vessel area/reference vessel area)x100%. Lesions were divided into three groups: compensatory enlargement (relative vessel area ≥105%), no-remodeling (relative vessel area between 95 and 105%) and shrinkage (relative vessel area ≤95%). Results: In 22 patients good images were obtained with both imaging modalities. More complex lesions were compensatory enlarged compared to shrunken lesions, whereas more smooth lesions were shrunken compared to compensatory enlarged lesions, 8/9 versus 2/7 and 5/7 versus 1/9, respectively (p=0.035). Conclusions: In patients selected for coronary intervention, angioscopic complex atherosclerotic lesions were found predominantly in compensatory enlarged arterial segments, whereas smooth lesions were found predominantly in shrunken arterial segments.

KEYWORDS Remodeling; Atherosclerosis; Coronary artery; Human; Angioscopy; Intravascular ultrasound

1 PCS was supported by the Dutch Heart Foundation, grant NHS 94-115.

2 GP is a fellow of the Catharijne Foundation, Utrecht, The Netherlands.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
O. C. Raffel, F. M. Merchant, G. J. Tearney, S. Chia, D. D. Gauthier, E. Pomerantsev, K. Mizuno, B. E. Bouma, and I.-K. Jang
In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography
Eur. Heart J., July 2, 2008; 29(14): 1721 - 1728.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.