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Cardiovascular Research 1999 41(2):395-401; doi:10.1016/S0008-6363(98)00302-2
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Cellular adhesion molecules on vascular smooth muscle cells

Marina Brauna,*, Peter Pietschb, Karsten Schröra, Gert Baumannb and Stephan B. Felixb

aInstitut für Pharmakologie, Heinrich-Heine-Universität, Moorenstrasse 5, D-40225 Düsseldorf, Germany
bMedizinische Klinik I, Charité, Humboldt-Universität zu Berlin, Berlin, Germany

* Corresponding author. Tel.: +49-211-811-2500; fax: +49-211-811-4781; e-mail: braunma@rz.uni-duesseldorf.de

Several studies during the last years have shown that, in addition to endothelial cells, vascular smooth muscle cells also express the cellular adhesion molecules ICAM-1 and VCAM-1 in atherosclerosis, restenosis and transplant vasculopathy. In vitro studies have characterized stimulatory and inhibitory factors that regulate the expression of ICAM-1 and VCAM-1 on cultured smooth muscle cells. There is evidence for a role of adhesion molecules on smooth muscle cells for leukocyte accumulation and activation of mononuclear cells. Some recent data suggest that the expression of adhesion molecules on smooth muscle cells are cell cycle-dependent and influence smooth muscle cell proliferation and differentiation. Therefore, ICAM-1 and VCAM-1 on smooth muscle cells may contribute to the inflammatory reaction in the vascular wall and may actively be involved in the progression and stability of atherosclerotic plaques.

KEYWORDS Smooth muscle cells; Atherosclerosis; Cytokines; Restenosis; Transplant vasculopathy


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