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Cardiovascular Research 1999 41(2):361-368; doi:10.1016/S0008-6363(98)00212-0
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture

Martin R Bennett*

British Heart Foundation Sr. Fellow, Addenbrooke's Hospital, Department of Medicine, Box 157, Cambridge CB2 2QQ, UK

* Tel.: +44-1223-331-504; fax: +44-1223-331-505; e-mail: mrb@mole.bio.cam.ac.uk

Apoptosis (programmed cell death) of vascular smooth muscle cells (VSMCs) has recently been identified as an important process in a variety of human vascular diseases, including atherosclerosis, arterial injury, and restenosis after angioplasty. VSMC apoptosis is regulated by interactions between the local cell–cell and cytokine environment within the arterial wall, and the expression of pro- and anti-apoptotic proteins by the cell, including death receptors, proto-oncogenes and tumour suppressor genes. This review summarises our current knowledge of the occurrence and mechanisms underlying VSMC apoptosis in atherosclerosis and arterial remodelling.

KEYWORDS Apoptosis; Vascular smooth muscle; Atherosclerosis; Human


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