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Cardiovascular Research 1999 41(2):345-360; doi:10.1016/S0008-6363(98)00286-7
© 1999 by European Society of Cardiology
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Copyright © 1999, European Society of Cardiology

Fibrous cap formation or destruction — the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation

Andrew C Newby* and Alla B Zaltsman

Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK

* Corresponding author. Tel.: +44-117-928-3582; fax: +44-117-928-3581; email: a.newby@bris.ac.uk

Endothelial activation and infiltration of monocyte macrophages are essential prerequisites for fibrous cap formation, which comprises proliferation and migration of smooth muscle cells and net matrix deposition. Macrophage foam cells and endothelium act as a source of growth factors and chemoattractants for smooth muscle cells. However, growth factors alone do not stimulate smooth muscle cell proliferation or migration. This requires, in addition, the remodelling of the extracellular matrix, at least partly mediated by metalloproteinases. In particular, loss of basement membrane components and contact with the interstitial matrix appears to be required to release a brake on proliferation and migration exerted by the basement membrane. Unless there is a change in the phenotype of macrophages in advanced lesions, it is not clear why fibrous cap destruction rather than formation should take place in macrophage-rich shoulder regions of plaques. Impaired cap formation caused by smooth muscle senescence, mummification and propensity to apoptosis may be as important as increased cap destruction in promoting plaque rupture.

KEYWORDS Arteriosclerosis; Vascular smooth muscle; Extracellular matrix; Metalloproteinases


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