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Cardiovascular Research 1998 40(3):546-556; doi:10.1016/S0008-6363(98)00199-0
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Effect of bolus epinephrine on systemic hemodynamics in canine anaphylactic shock

S.N. Mink*, C. Bands, A. Becker, J. Elkin, S. Sharma, H. Unruh and W. Kepron

Department of Internal Medicine, Surgery, Pediatrics, and Immunology, University of Manitoba, Winnipeg, Manitoba, Canada

* Corresponding author. Tel.: +1-204-787-2684; fax: +1-204-787-4826.

Objective: Epinephrine (Epi) is considered to be the drug of choice for anaphylactic shock (AS). However, the benefit of this drug on improving systemic hemodynamics in AS has never been shown. We used a canine ragweed model of AS to determine if an intravenous bolus of Epi hastened the recovery of hemodynamics and modified mediator release (Med) compared with no treatment (NT). Methods: In one protocol (n=8), the effects on hemodynamics of two intravenous doses of Epi (0.01 and 0.025 mg/kg) were examined for 3 h postshock in respective studies approximately three weeks apart under pentobarbital anesthesia in the same animal. In five other dogs, left ventricular (LV) mechanics were additionally determined by sonomicrometric techniques to determine changes in contractility as defined by the preload recruitable stroke–work (SW) relationship. Results: Compared with NT values, Epi treatments produced only transient increases in mean arterial pressure (MAP) and cardiac output (CO) post-challenge. By 20 min postshock, CO in the Epi studies were generally lower (p<0.05) and BP was not different from NT values. With Epi treatment, SW was reduced for a given LV end-diastolic volume compared with the control study. Epi treatments also caused relatively higher plasma thromboxane B2 concentrations postshock. Conclusion: Our findings indicate that, when given immediately postshock, bolus-Epi did not hasten recovery and caused impairment in LV mechanics in canine AS.

KEYWORDS Allergy; Asthma; Mediators; Canine


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