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Cardiovascular Research 1998 40(3):426-432; doi:10.1016/S0008-6363(98)00244-2
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

The role of oxidative stress in the genesis of heart disease

Pawan K Singala,b,*, Neelam Khapera,b, Vince Palacea,b and Dinender Kumara,b

aInstitute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Avenue, R3022, Winnipeg, MB R2H 2A6, Canada
bDepartment of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

* Corresponding author. Tel.: +204-235-3416; fax: +204-233-6723; e-mail: psingal@sbrc.umanitoba.ca

Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only began to take notice of these noxious species in the 1970s. Exponential growth of free radical research occurred after the discovery of superoxide dismutase in 1969. This antioxidant enzyme is responsible for the dismutation of superoxide radical — a free radical chain initiator. A fine balance between free radicals and a variety of endogenous antioxidants is believed to exist. Any disturbance in this equilibrium in favour of free radicals causes an increase in oxidative stress and initiates subcellular changes leading to cardiomyopathy and heart failure. Our knowledge about the role of free radicals in the pathogenesis of cardiac dysfunction is fast approaching the point where newer therapies employing antioxidants are in sight.

KEYWORDS Free radicals; Antioxidants; Heart failure


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