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Cardiovascular Research 1998 40(2):389-395; doi:10.1016/S0008-6363(98)00130-8
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Procoagulant and proinflammatory activity in acute coronary syndromes

Annemieke Mantena, Robbert J. de Winterb,*, Monique C. Minnemaa, Hugo ten Cated,e, Jeroen G. Lijmerc, Rob Adamsb, Ron J.G. Petersb and Sander J.H. van Deventerd

aCenter for Hemostasis, Thrombosis, Atherosclerosis, and Inflammation Research, Academic Medical Hospital, Slotervaartziekenhuis, Amsterdam, Netherlands
bDepartment of Cardiology, Room G3-231, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
cDepartment of Clinical Epidemiology and Biostatics, Slotervaartziekenhuis, Amsterdam, Netherlands
dDepartment of Experimental Internal Medicine, Academic Medical Hospital, University of Amsterdam, Slotervaartziekenhuis, Amsterdam, Netherlands
eDepartment of Internal Medicine, Slotervaartziekenhuis, Amsterdam, Netherlands

* Corresponding author: Tel.: 00 31 20 566 9111; Fax: 00 31 20 691 5687; E-mail: R.J.dewinter@AMC.UVA.NL

Objectives: Both the hemostatic and inflammatory system are thought to play a role in the pathogenesis of acute coronary syndromes. However, their respective contribution and interrelationship remain unclear, therefore, we studied the relationship between activation of the coagulation system and proinflammatory activity in ischemic coronary syndromes. Methods: Thrombin–antithrombin III (TAT), prothrombin fragments F1+2, fibrinopeptide A (FPA), interleukin-6 (IL-6) and interleukin-8 (IL-8) were measured in 50 patients with unstable angina (UA), 60 patients with acute myocardial infarction (AMI) and in 50 patients with stable angina (SA). Results: FPA levels were significantly higher in patients with UA and AMI than in patients with SA (p=0.0015 and p<0.0001), and were higher in patients with AMI than UA (p=0.0013). Plasma IL-6 concentrations were significantly higher in patients with UA and AMI than in patients with SA (p=0.0020 and p<0.001), and again were higher in AMI than UA (p=0.001). Interestingly, FPA or IL-6 elevations on admission were found in different patients. In contrast, TAT, F1+2 and IL-8 levels were not different between the three groups. Conclusions: IL-6 and FPA were shown to be independent predictive markers with equal discriminative power to distinguish stable (SA) from unstable (UA+AMI) patients. Moreover, hemostatic and inflammatory markers can be elevated independently in the acute phase of ischemic coronary syndromes.

KEYWORDS Acute coronary syndromes; Coronary disease; Cytokines; Coagulation


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