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Cardiovascular Research 1998 40(1):9-22; doi:10.1016/S0008-6363(98)00142-4
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review

Boris Z. Simkhovich*, Karin Przyklenk and Robert A. Kloner

Heart Institute, Good Samaritan Hospital and Department of Medicine (Section of Cardiology), University of Southern California, Los Angeles, CA 90017, USA

* Corresponding author. Tel.: +1 (213) 977 4194; Fax: +1 (213) 977 4107.

Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic preconditioning. However, the role of PKC in eliciting cardioprotection remains controversial. In this review, we summarize the evidence for and against the ‘PKC hypothesis’ of preconditioning, discuss the important technical limitations currently hampering PKC research, and suggest new approaches (i.e. PKC isoform-specific biochemical assays combined with immunoblotting techniques) that might aid in the definite resolution of this issue.

KEYWORDS Ischemic preconditioning; Protein kinase C; Signal transduction


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