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Cardiovascular Research 1998 40(1):88-95; doi:10.1016/S0008-6363(98)00119-9
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Left coronary pressure–flow relations of the beating and arrested rabbit heart at different ventricular volumes

Pieter Sipkema*, Johanna J.M Takkenberg, Petra E.M Zeeuwe and Nicolaas Westerhof

Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit (ICaR-VU), Amsterdam, The Netherlands

* Corresponding author. Tel.: +31 (20) 444 8110; Fax: +31 (20) 444 8255; E-mail: p.sipkema.physiol@med.vu.nl

Objective: To study the effect of cardiac contraction on left coronary artery pressure–flow relations at different vascular volumes and to compare these relations in the beating heart with those in the heart arrested in systole and diastole. Methods: Maximally vasodilated, Tyrode perfused, rabbit hearts (n=6) with an intra-ventricular balloon were used. The left coronary artery was separately perfused via a cannula in the left main coronary artery. The slopes and the intercepts of left coronary pressure-flow relations were determined in the beating and arrested heart at different chamber volumes. A 3-factor design with repeated measures was used to compare the effect of three factors: phase of contraction (systole and diastole), chamber volume (V0 and V1, left ventricular end-diastolic pressure 1.4 and 20 mm Hg, respectively) and the type of contraction (beating and arrested; a measure of capacitive effects). Results: The phase of contraction has a significant effect on the intercepts (>40 mmHg, p=0.00032) but not on the slopes of the pressure–flow relations. Chamber volume had a small effect on the intercepts (<5 mm Hg, p=0.037), but not on the slopes of the pressure–flow relations. The type of contraction has a significant effect on the slopes (~10%, p=0.00021) but not on the intercepts of the pressure–flow relations. Conclusions: In the isolated Tyrode perfused rabbit heart left coronary pressure–flow relations are mainly determined by contraction, while left ventricular chamber volume and capacitive effects contribute little.

KEYWORDS Diastolic arrest; KCl; Barium contracture; Isolated heart; Left ventricular pressure; Rabbit


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