Skip Navigation

Cardiovascular Research 1998 38(2):472-479; doi:10.1016/S0008-6363(98)00028-5
© 1998 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tavernier, B.
Right arrow Articles by Adnet, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tavernier, B.
Right arrow Articles by Adnet, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1998, European Society of Cardiology

Myofilament calcium sensitivity is decreased in skinned cardiac fibres of endotoxin-treated rabbits

Benoît Taverniera,*, Delphine Garrigueb, Claire Boulleb, Benoît Valleta and Pascal Adnetb

aDépartement d'Anesthésie-Réanimation Chirurgicale 2, Centre Hospitalier Régional et Universitaire de Lille, 59037 Lille Cedex, France
bService d'Accueil des Urgences, Centre Hospitalier Régional et Universitaire de Lille, 59037 Lille Cedex, France

* Corresponding author. Département d'Anesthésie-Réanimation Chirurgicale 2, Hopital Huriez, Centre Hospitalier Régional et Universitaire, 59037 Lille Cedex, France. Tel.: +33 320 444508; fax: +33 320 444508.

Objective: The aim was to determine whether myofilament Ca2+ sensitivity is altered in skinned cardiac fibres from endotoxin-treated rabbits. Methods: Endotoxin was injected i.v. in conscious New-Zealand White rabbits at a dose of 0.5 mg/kg (groups I, II, and III) or 1 mg/kg (group IV). A fifth group was used as control. Hearts were excised 4 h (groups I and IV), 24 h (group II), or 5 days (Group III) after injection. Skinned fibres were obtained with chemical (EGTA+Brij 58) treatment of bundles isolated from papillary muscles. Results: The maximal Ca2+-activated force (F0) of skinned cardiac fibres was not different between groups. However, [Ca2+] required to evoke 50% of F0 (Ca50) was higher in the fibres from group I than in controls (1.78±0.05 vs. 1.53±0.03 µM; P<0.05). This effect was dose-dependent (group IV: Ca50=2.08±0.12 µM; P<0.05 vs. group I), larger after 24 h (group II: Ca50=2.12±0.05 µM; P<0.05 vs. group I). By 5 days, myofilament Ca2+ sensitivity had returned to normal (group III: Ca50=1.54±0.05 µM). Conclusion: Myofilament Ca2+ sensitivity is decreased in skinned fibres taken from rabbit myocardium after i.v. endotoxin injection. This effect is dose- and time-dependent, and reversible with time.

KEYWORDS Endotoxin; Cardiac function; Contractile apparatus; Calcium ion; Rabbit


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
D. Cunha-Goncalves, V. Perez-de-Sa, E. Grins, P. L. Dahm, J. Thorne, and S. Blomquist
Inotropic Support During Experimental Endotoxemic Shock: Part I. The Effects of Levosimendan on Splanchnic Perfusion
Anesth. Analg., November 1, 2009; 109(5): 1568 - 1575.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
R. Pirracchio, B. Cholley, S. De Hert, A. C. Solal, and A. Mebazaa
Diastolic heart failure in anaesthesia and critical care
Br. J. Anaesth., June 1, 2007; 98(6): 707 - 721.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Mansart, P.-E. Bollaert, P. Giummelly, C. Capdeville-Atkinson, and J. Atkinson
Effects of dexamethasone and L-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1177 - H1182.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
R. A. Zager
Parenteral Iron Compounds: Potent Oxidants but Mainstays of Anemia Management in Chronic Renal Disease
Clin. J. Am. Soc. Nephrol., September 1, 2006; 1(Supplement_1): S24 - S31.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. A. Zager, A. C. Johnson, S. Lund, S. Y. Hanson, and C. K. Abrass
Levosimendan protects against experimental endotoxemic acute renal failure
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1453 - F1462.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Layland, R. J. Solaro, and A. M. Shah
Regulation of cardiac contractile function by troponin I phosphorylation
Cardiovasc Res, April 1, 2005; 66(1): 12 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. TAVERNIER, A. MEBAZAA, P. MATEO, S. SYS, R. VENTURA-CLAPIER, and V. VEKSLER
Phosphorylation-dependent Alteration in Myofilament Ca2+ Sensitivity but Normal Mitochondrial Function in Septic Heart
Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 362 - 367.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. ABI-GERGES, B. TAVERNIER, A. MEBAZAA, V. FAIVRE, X. PAQUERON, D. PAYEN, R. FISCHMEISTER, and P.-F. MÉRY
Sequential Changes in Autonomic Regulation of Cardiac Myocytes after In Vivo Endotoxin Injection in Rat
Am. J. Respir. Crit. Care Med., October 1, 1999; 160(4): 1196 - 1204.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.