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Cardiovascular Research 1998 37(1):42-45; doi:10.1016/S0008-6363(97)00211-3
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Prevalence of the prothrombin gene variant 20210 G->A among patients with myocardial infarction

Valder R Arrudaa,*, Lucia H Siquieraa, Luiz C Chiaparinia, Otavio R Coelhoa, Antonio P Mansurb, Antonio Ramiresb and Joyce M Annichino-Bizzacchia

aHematology–Hemotherapy Center, State University of Campinas, C.P. 6198, C.E.P. 13081-970, Campinas, SP Brazil
bHeart Institute, University of São Paulo, São Paulo, Brazil

* Corresponding author. Fax: +55-19-788-8750/+55-192-393511; E-mail: vrarruda@hotmail.com

Objective: The aim of this study was to determine the prevalence of the prothrombin variant allele 20210A among survivors of myocardial infarction Background: The prothrombin gene variant has been identified as a novel genetic risk factor for venous thrombosis. However, the risk of developing arterial thrombosis as a result of the presence of this mutated allele is unknown. Methods: The G->A transition at position 20210 of the 3'-untranslated region was determined in 220 survivors of myocardial infarction and in 295 individuals from the general population. Results: The prevalence of heterozygotes for the prothrombin mutated allele was 3% among patients with myocardial infarction and 0.7% in the general population (P = 0.03). No age-related difference in the prevalence of the mutated allele was observed. However, for individuals over 45 years old the prevalence among females was higher than among males (5% vs. 0%). Conclusion: These data suggest that being heterozygote for the allele variant 20210A of the prothrombin gene could be a genetic risk factor for developing myocardial infarction.

KEYWORDS Myocardial infarction; Risk factors; Prothrombin; DNA polymorphism


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