© 1998 by European Society of Cardiology
Copyright © 1998, European Society of Cardiology
Ischaemic preconditioning: present position and future directions1
aThe Hatter Institute for Cardiovascular Studies, Division of Cardiology, University College London Hospitals and Medical School, Grafton Way, London WC1E 6DB, UK
bHospital General Universitari Vall d'Hebron, Barcelona, Spain
cAbteilung fur Pathophysiologie, Universitatsklinikum, Essen, Germany
* Corresponding author. Tel. +44-0-171-380-9888; Fax +44-0-171-388-5095; E-mail: s.bush-cavell@ucl.ac.uk
Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective adaptation of the myocyte has also been observed in other cell types. The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concerning the pathophysiology of ischemia-reperfusion injury and the regulatory mechanisms underlying cellular metabolism. We feel it is timely to assess the current position in this field and provide a critical appraisal to facilitate future research.
KEYWORDS Ischemic preconditioning; Myocardium; Myocardial protection
1 On behalf of participants of the EEC Biomed Concerted Action "The New Ischaemic Syndromes".
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
H. Ishii, T. Amano, T. Matsubara, and T. Murohara Pharmacological Intervention for Prevention of Left Ventricular Remodeling and Improving Prognosis in Myocardial Infarction Circulation, December 16, 2008; 118(25): 2710 - 2718. [Full Text] [PDF] |
||||
![]() |
R. M. Mentzer Jr, M. S. Jahania, and R. D. Lasley Myocardial Protection Card. Surg. Adult, January 1, 2008; 3(2008): 443 - 464. [Full Text] |
||||
![]() |
P. Ferdinandy, R. Schulz, and G. F. Baxter Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning Pharmacol. Rev., December 1, 2007; 59(4): 418 - 458. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. A. R. Paiva, R. Novo, B. B. Matsubara, L. S. Matsubara, P. S. Azevedo, M. F. Minicucci, A. O. Campana, and L. A. M. Zornoff {beta}-Carotene Attenuates the Paradoxical Effect of Tobacco Smoke on the Mortality of Rats after Experimental Myocardial Infarction J. Nutr., September 1, 2005; 135(9): 2109 - 2113. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. K. Gamperl, H. A. Faust, B. Dougher, and K. J. Rodnick Hypoxia tolerance and preconditioning are not additive in the trout (Oncorhynchus mykiss) heart J. Exp. Biol., June 15, 2004; 207(14): 2497 - 2505. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. T Dirksen, G. Laarman, A. W.J van 't Hof, G. Guagliumi, W. A.L Tonino, L. Tavazzi, D. J.G.M Duncker, M. L Simoons, and on behalf of the PARI-MI Investigators The effect of ITF-1697 on reperfusion in patients undergoing primary angioplasty: Safety and efficacy of a novel tetrapeptide, ITF-1697 Eur. Heart J., March 1, 2004; 25(5): 392 - 400. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Carini, R. Castino, M. G. De Cesaris, R. Splendore, M. Demoz, E. Albano, and C. Isidoro Preconditioning-induced cytoprotection in hepatocytes requires Ca2+-dependent exocytosis of lysosomes J. Cell Sci., March 1, 2004; 117(7): 1065 - 1077. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Dazert, K. Meissner, S. Vogelgesang, B. Heydrich, L. Eckel, M. Bohm, R. Warzok, R. Kerb, U. Brinkmann, E. Schaeffeler, et al. Expression and Localization of the Multidrug Resistance Protein 5 (MRP5/ABCC5), a Cellular Export Pump for Cyclic Nucleotides, in Human Heart Am. J. Pathol., October 1, 2003; 163(4): 1567 - 1577. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Rui, G. Cepinskas, Q. Feng, and P. R Kvietys Delayed preconditioning in cardiac myocytes with respect to development of a proinflammatory phenotype: role of SOD and NOS Cardiovasc Res, October 1, 2003; 59(4): 901 - 911. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. B. Elmoselhi, A. Lukas, P. Ostadal, and N. S. Dhalla Preconditioning attenuates ischemia-reperfusion-induced remodeling of Na+-K+-ATPase in hearts Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1055 - H1063. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. N. Peart and G. J. Gross Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H81 - H89. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. J. Penttila, M. V.K. Lepojarvi, P. K. Kaukoranta, K. T. Kiviluoma, K. V. Ylitalo, and K. J. Peuhkurinen Ischemic preconditioning does not improve myocardial preservation during off-pump multivessel coronary operation Ann. Thorac. Surg., April 1, 2003; 75(4): 1246 - 1252. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Martire, B. Fernandez, A. Buehler, C. Strohm, J. Schaper, R. Zimmermann, P. E Kolattukudy, and W. Schaper Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice mimics ischemic preconditioning through SAPK/JNK1/2 activation Cardiovasc Res, February 1, 2003; 57(2): 523 - 534. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. M. Mentzer Jr., M. S. Jahania, and R. D. Lasley Myocardial Protection Card. Surg. Adult, January 1, 2003; 2(2003): 413 - 438. [Full Text] |
||||
![]() |
J. M. Gordon, G. J. Dusting, O. L. Woodman, and R. H. Ritchie Cardioprotective action of CRF peptide urocortin against simulated ischemia in adult rat cardiomyocytes Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H330 - H336. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Taggart and D. M. Yellon Preconditioning and Arrhythmias Circulation, December 10, 2002; 106(24): 2999 - 3001. [Full Text] [PDF] |
||||
![]() |
K. Shinmura, M. Nagai, K. Tamaki, M. Tani, and R. Bolli COX-2-derived prostacyclin mediates opioid-induced late phase of preconditioning in isolated rat hearts Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2534 - H2543. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. K Reddy, S. K.G Koshy, and H. Shukia Triggers and promoters of ischaemic preconditioning Cardiovasc Res, October 1, 2002; 56(1): 1 - 3. [Full Text] [PDF] |
||||
![]() |
O. P. Elvenes, C. Korvald, R. Myklebust, and D. Sorlie Warm retrograde blood cardioplegia saves more ischemic myocardium but may cause a functional impairment compared to cold crystalloid Eur. J. Cardiothorac. Surg., September 1, 2002; 22(3): 402 - 409. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Garcia-Dorado, M. Ruiz-Meana, F. Padilla, A. Rodriguez-Sinovas, and M. Mirabet Gap junction-mediated intercellular communication in ischemic preconditioning Cardiovasc Res, August 15, 2002; 55(3): 456 - 465. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Neckar, O. Szarszoi, L. Koten, F. Papousek, B. Ost'adal, G. J Grover, and F. Kolar Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats Cardiovasc Res, August 15, 2002; 55(3): 567 - 575. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Wolfrum, K. Schneider, M. Heidbreder, J. Nienstedt, P. Dominiak, and A. Dendorfer Remote preconditioning protects the heart by activating myocardial PKC{epsilon}-isoform Cardiovasc Res, August 15, 2002; 55(3): 583 - 589. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Strohm, M. Barancik, M.-L. von Bruehl, M. Strniskova, C. Ullmann, R. Zimmermann, and W. Schaper Transcription inhibitor actinomycin-D abolishes the cardioprotective effect of ischemic reconditioning Cardiovasc Res, August 15, 2002; 55(3): 602 - 618. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Gres, R. Schulz, J. Jansen, C. Umschlag, and G. Heusch Involvement of endogenous prostaglandins in ischemic preconditioning in pigs Cardiovasc Res, August 15, 2002; 55(3): 626 - 632. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Tanoue, P. Herijgers, B. Meuris, E. Verbeken, V. Leunens, M. Lox, and W. Flameng Ischemic preconditioning reduces unloaded myocardial oxygen consumption in an in-vivo sheep model* Cardiovasc Res, August 15, 2002; 55(3): 633 - 641. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. F del Valle, E. C Lascano, and J. A Negroni Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channels Cardiovasc Res, August 15, 2002; 55(3): 642 - 659. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Babsky, S. Hekmatyar, S. Wehrli, N. Doliba, M. Osbakken, and N. Bansal Influence of Ischemic Preconditioning on Intracellular Sodium, pH, and Cellular Energy Status in Isolated Perfused Heart Experimental Biology and Medicine, July 1, 2002; 227(7): 520 - 528. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. J. Gross and D. C. Warltier Prologue: nonclassical modalities of myocardial preconditioning Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1951 - H1952. [Full Text] [PDF] |
||||
![]() |
A. K. Gamperl, A. E. Todgham, W. S. Parkhouse, R. Dill, and A. P. Farrell Recovery of trout myocardial function following anoxia: preconditioning in a non-mammalian model Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1755 - R1763. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. B. A. Menown and A. A. J. Adgey Cardioprotective therapy and sodium-hydrogen exchange inhibition: current concepts and future goals J. Am. Coll. Cardiol., November 15, 2001; 38(6): 1651 - 1653. [Full Text] [PDF] |
||||
![]() |
M. Karck, S. Tanaka, S. F. Bolling, A. Simon, T.-P. Su, P. R. Oeltgen, and A. Haverich Myocardial protection by ischemic preconditioning and {delta}-opioid receptor activation in the isolated working rat heart J. Thorac. Cardiovasc. Surg., November 1, 2001; 122(5): 986 - 992. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Schulz, M. V Cohen, M. Behrends, J. M Downey, and G. Heusch Signal transduction of ischemic preconditioning Cardiovasc Res, November 1, 2001; 52(2): 181 - 198. [Full Text] [PDF] |
||||
![]() |
M. M. Mocanu, H. L. Maddock, G. F. Baxter, C. L. Lawrence, N. B. Standen, and D. M. Yellon Glimepiride, a Novel Sulfonylurea, Does Not Abolish Myocardial Protection Afforded by Either Ischemic Preconditioning or Diazoxide Circulation, June 26, 2001; 103(25): 3111 - 3116. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Heusch Nitroglycerin and Delayed Preconditioning in Humans : Yet Another New Mechanism for an Old Drug? Circulation, June 19, 2001; 103(24): 2876 - 2878. [Full Text] [PDF] |
||||
![]() |
T. L. Clanton and P. F. Klawitter Physiological and Genomic Consequences of Intermittent Hypoxia: Invited Review: Adaptive responses of skeletal muscle to intermittent hypoxia: the known and the unknown J Appl Physiol, June 1, 2001; 90(6): 2476 - 2487. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. T. Jaberansari, G. F. Baxter, C. A. Muller, S. E. Latouf, E. Roth, L. H. Opie, and D. M. Yellon Angiotensin-converting enzyme inhibition enhances a subthreshold stimulus to elicit delayed preconditioning in pig myocardium J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1996 - 2001. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Ruiz-Meana, D. Garcia-Dorado, S. Lane, P. Pina, J. Inserte, M. Mirabet, and J. Soler-Soler Persistence of gap junction communication during myocardial ischemia Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2563 - H2571. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Schulz, P. Gres, and G. Heusch Role of endogenous opioids in ischemic preconditioning but not in short-term hibernation in pigs Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2175 - H2181. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Wang, G. Cherednichenko, L. Hernandez, J. Halow, S. A. Camacho, V. Figueredo, and S. Schaefer Preconditioning limits mitochondrial Ca2+ during ischemia in rat hearts: role of KATP channels Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H2321 - H2328. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Zucchi, G. Yu, S. Ghelardoni, F. Ronca, and S. Ronca-Testoni A3 adenosine receptor stimulation modulates sarcoplasmic reticulum Ca2+ release in rat heart Cardiovasc Res, April 1, 2001; 50(1): 56 - 64. [Abstract] [Full Text] [PDF] |
||||
![]() |
X-H. Xiao and D.G. Allen Activity of the Na+/H+ exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart Cardiovasc Res, November 1, 2000; 48(2): 244 - 253. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. R. Tracey, W. P. Magee, C. A. Ellery, J. T. MacAndrew, A. H. Smith, D. R. Knight, and P. J. Oates Aldose reductase inhibition alone or combined with an adenosine A3 agonist reduces ischemic myocardial injury Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1447 - H1452. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. M. Yellon and A. Dana The Preconditioning Phenomenon : A Tool for the Scientist or a Clinical Reality? Circ. Res., September 29, 2000; 87(7): 543 - 550. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. R. Morrison, R. Jones, A. M. Byford, A. R. Stell, J. Peart, J. P. Headrick, and G. P. Matherne Transgenic overexpression of cardiac A1 adenosine receptors mimics ischemic preconditioning Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1071 - H1078. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J. Pomerantz, T. N. Robinson, T. D. Morrell, J. K. Heimbach, A. Banerjee, and A. H. Harken Selective mitochondrial adenosine triphosphate-sensitive potassium channel activation is sufficient to precondition human myocardium J. Thorac. Cardiovasc. Surg., August 1, 2000; 120(2): 387 - 392. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kawasuji, M. Ikeda, N. Sakakibara, S. Fujii, S. Tomita, and Y. Watanabe Near-infrared monitoring of myocardial oxygenation during ischemic preconditioning Ann. Thorac. Surg., June 1, 2000; 69(6): 1806 - 1810. [Abstract] [Full Text] [PDF] |
||||
![]() |
D M Yellon and G F Baxter Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality? Heart, April 1, 2000; 83(4): 381 - 387. [Full Text] |
||||
![]() |
S. ZAHLER, C. KUPATT, and B. F. BECKER Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-{alpha} FASEB J, March 1, 2000; 14(3): 555 - 564. [Abstract] [Full Text] |
||||
![]() |
C. W. Lush, G. Cepinskas, and P. R. Kvietys LPS tolerance in human endothelial cells: reduced PMN adhesion, E-selectin expression, and NF-kappa B mobilization Am J Physiol Heart Circ Physiol, March 1, 2000; 278(3): H853 - H861. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. T. Lee and C. W. Emala Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A1 and A3 receptors Am J Physiol Renal Physiol, March 1, 2000; 278(3): F380 - F387. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.-I. Kawabata, T. Netticadan, M. Osada, K. Tamura, and N. S. Dhalla Mechanisms of ischemic preconditioning effects on Ca2+ paradox-induced changes in heart Am J Physiol Heart Circ Physiol, March 1, 2000; 278(3): H1008 - H1015. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Inserte, G. Taimor, B. Hofstaetter, D. Garcia-Dorado, and H. M. Piper Influence of simulated ischemia on apoptosis induction by oxidative stress in adult cardiomyocytes of rats Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H94 - H99. [Abstract] [Full Text] [PDF] |
||||
![]() |
X.-H. Xiao and D. G. Allen Role of Na+/H+ Exchanger During Ischemia and Preconditioning in the Isolated Rat Heart Circ. Res., October 15, 1999; 85(8): 723 - 730. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. de Jonge and J. W. de Jong Ischemic preconditioning and glucose metabolism during low-flow ischemia: Role of the adenosine A1 receptor Cardiovasc Res, September 1, 1999; 43(4): 909 - 918. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Joyeux, P. Faure, D. Godin-Ribuot, S. Halimi, A. Patel, D. M Yellon, P. Demenge, and C. Ribuot Heat stress fails to protect myocardium of streptozotocin-induced diabetic rats against infarction Cardiovasc Res, September 1, 1999; 43(4): 939 - 946. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. D Rakhit, R. J Edwards, and M. S Marber Nitric oxide, nitrates and ischaemic preconditioning Cardiovasc Res, August 15, 1999; 43(3): 621 - 627. [Full Text] [PDF] |
||||
![]() |
E. N. Morgan, E. M. Boyle Jr, W. Yun, J. M. Griscavage-Ennis, A. L. Farr, T. G. Canty Jr, T. H. Pohlman, and E. D. Verrier An essential role for NF-{kappa}B in the cardioadaptive response to ischemia Ann. Thorac. Surg., August 1, 1999; 68(2): 377 - 382. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. H. Strasser, G. Simonis, S. P. Schon, M. U. Braun, R. Ihl-Vahl, C. Weinbrenner, R. Marquetant, and W. Kubler Two Distinct Mechanisms Mediate a Differential Regulation of Protein Kinase C Isozymes in Acute and Prolonged Myocardial Ischemia Circ. Res., July 9, 1999; 85(1): 77 - 87. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-S. V. Chen, S. C. Body, and S. K. Shernan Myocardial Preconditioning: Characteristics, Mechanisms, and Clinical Applications Seminars in Cardiothoracic and Vascular Anesthesia, July 1, 1999; 3(2): 85 - 97. [Abstract] [PDF] |
||||
![]() |
B. Ostadal, I. Ostadalova, and N. S. Dhalla Development of Cardiac Sensitivity to Oxygen Deficiency: Comparative and Ontogenetic Aspects Physiol Rev, July 1, 1999; 79(3): 635 - 659. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Takeo and Y. Nasa Role of energy metabolism in the preconditioned heart - a possible contribution of mitochondria Cardiovasc Res, July 1, 1999; 43(1): 32 - 43. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Ginis, U. Schweizer, M. Brenner, J. Liu, N. Azzam, M. Spatz, and J. M. Hallenbeck TNF-alpha pretreatment prevents subsequent activation of cultured brain cells with TNF-alpha and hypoxia via ceramide Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1171 - C1183. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Billinger, M. Fleisch, F. R. Eberli, A. Garachemani, B. Meier, and C. Seiler Is the development of myocardial tolerance to repeated ischemia in humans due to preconditioning or to collateral recruitment? J. Am. Coll. Cardiol., March 15, 1999; 33(4): 1027 - 1035. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. E. Baker, P. Holman, and G. J. Gross Preconditioning in Immature Rabbit Hearts : Role of KATP Channels Circulation, March 9, 1999; 99(9): 1249 - 1254. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Joyeux, C. Lagneux, G. Bricca, D. M. Yellon, P. Demenge, and C. Ribuot Heat stress-induced resistance to myocardial infarction in the isolated heart from transgenic [(mREN-2)27] hypertensive rats Cardiovasc Res, October 1, 1998; 40(1): 124 - 130. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. C. Barone, R. F. White, P. A. Spera, J. Ellison, R. W. Currie, X. Wang, G. Z. Feuerstein, and N. J. Rothwell Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression • Editorial Comment Stroke, September 1, 1998; 29(9): 1937 - 1951. [Abstract] [Full Text] [PDF] |
||||
























