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Cardiovascular Research 1998 37(1):21-33; doi:10.1016/S0008-6363(97)00214-9
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Ischaemic preconditioning: present position and future directions1

Derek M Yellona,*, Gary F Baxtera, David Garcia-Doradob, Gerd Heuschc and Mark S Sumeraya

aThe Hatter Institute for Cardiovascular Studies, Division of Cardiology, University College London Hospitals and Medical School, Grafton Way, London WC1E 6DB, UK
bHospital General Universitari Vall d'Hebron, Barcelona, Spain
cAbteilung fur Pathophysiologie, Universitatsklinikum, Essen, Germany

* Corresponding author. Tel. +44-0-171-380-9888; Fax +44-0-171-388-5095; E-mail: s.bush-cavell@ucl.ac.uk

Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective adaptation of the myocyte has also been observed in other cell types. The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concerning the pathophysiology of ischemia-reperfusion injury and the regulatory mechanisms underlying cellular metabolism. We feel it is timely to assess the current position in this field and provide a critical appraisal to facilitate future research.

KEYWORDS Ischemic preconditioning; Myocardium; Myocardial protection

1 On behalf of participants of the EEC Biomed Concerted Action "The New Ischaemic Syndromes".


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[Abstract] [PDF]


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