© 1997 by European Society of Cardiology
Copyright © 1997, European Society of Cardiology
Is oxidative stress causally linked to unstable angina pectoris? A study in 100 CAD patients and matched controls
Department of Cardiology, University of Vienna, Waehringerguertel 18–20, A-1090 Vienna, Austria
* Corresponding author. Tel. (+43) 1 40400 4623; Fax (+43) 1 40400 4624.
Objective: Unstable angina pectoris often leads to acute myocardial infarction. Since lipid peroxidation is thought to be causally related to chronic and acute events in atherosclerosis and coronary artery disease, we measured lipid peroxidation products and vitamin E in 100 patients with coronary artery disease and compared them to a matched control group. Methods: 50 consecutive patients with stable angina pectoris (SAP) and 50 consecutive patients with unstable angina pectoris (UAP) were studied and compared to 100 clinically healthy individuals. In addition to conventional lipid and lipoprotein analysis, malondialdehydes were measured as thiobarbituric acid reactive substances (TBARS). Lipid hydroperoxides were assayed with the colorimetric methylene blue method. 
-Tocopherol was quantitated by HPLC after extraction of serum with hexane–ethanol. In the patient group conjugated dienes were also measured. Results: As expected, patients had significantly higher cholesterol, triglyceride LDL-C and Lp(a) values and lower HDL-C values than controls. When patients were divided into groups with SAP and UAP respectively, peroxides and TBARS were significantly higher in the latter group as compared to patients with SAP and to controls. Conjugated dienes were also significantly higher in patients with UAP as compared to patients with SAP. Total plasma -tocopherol was comparable in all three groups, whereas the -tocopherol content per LDL particle was lowest in patients with UAP, followed by patients with SAP and then controls. Conclusion: It is concluded that lipid peroxidation parameters are increased in patients with UAP and discriminate SAP from UAP patients.
KEYWORDS TBARS: thiobarbituric acid reactive substances; UAP: unstable angina pectoris; SAP: stable angina pectoris
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