Skip Navigation

Cardiovascular Research 1997 36(1):37-44; doi:10.1016/S0008-6363(97)00143-0
© 1997 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Miwa, K.
Right arrow Articles by Inoue, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miwa, K.
Right arrow Articles by Inoue, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1997, European Society of Cardiology

Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina

Kunihisa Miwa*, Akihiko Igawa and Hiroshi Inoue

The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

* Corresponding author. Tel.: +81-764-34-2281, ext. 2507; fax: +81-764-34-5026.

Objective: The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation. Methods: Antecubital venous plasma samples were collected from 33 patients with variant angina, 22 patients with stable effort angina and 20 control subjects. Samples were also collected from the aortic root (AO) and the coronary sinus (CS) in 18 patients with variant angina before and after left coronary spasm induced by intracoronary injection of acetylcholine. The soluble adhesion molecules were assayed by enzyme immunoassay. Results: Antecubital venous plasma soluble E-selectin (P<.05), ICAM-1 (P<.01) and VCAM-1 (NS) levels were higher in the variant angina group than in the control group, respectively. The plasma soluble ICAM-1 level was also higher (P<.01) in the variant angina group than in the stable effort angina group. In the variant angina group, both soluble ICAM-1 (P<.05) and VCAM-1 (P<.01) levels were significantly lower in CS than AO at baseline. In contrast, after the spasm the plasma soluble ICAM-1 level was (P<.05) higher in CS than AO and the CS–AO differences of soluble ICAM-1 (P<.05) and VCAM-1 (P<.05) increased as compared with the baseline, respectively. These values were remained unchanged in the stable effort angina group after rapid atrial pacing and in the control group after administration of acetylcholine. Conclusions: Circulating plasma levels of both soluble E-selectin and ICAM-1 were elevated in patients with variant angina, indicating an association of an inflammatory reaction with coronary spasm. Both soluble ICAM-1 and VCAM-1 appeared to be trapped in the coronary circulation at baseline and released into the coronary circulation following coronary spasm and reperfusion in the patients.

KEYWORDS Unstable angina; Variant angina; Coronary artery spasm; Ischemia/reperfusion; Soluble adhesion molecule; Human


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
E. Giannitsis and H. A. Katus
Ability of DNase I activity to detect myocardial ischaemia in vasospastic angina a view through a monocle?
Eur. Heart J., December 2, 2007; 28(24): 2955 - 2956.
[Full Text] [PDF]

Home page
 StrokeHome page
A. D. Blann, P. M. Ridker, and G. Y.H. Lip
Inflammation, Cell Adhesion Molecules, and Stroke: Tools in Pathophysiology and Epidemiology?
Stroke, September 1, 2002; 33(9): 2141 - 2143.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
T O'malley, C.A Ludlam, R.A Riemermsa, and K.A.A Fox
Early increase in levels of soluble inter-cellular adhesion molecule-1 (sICAM-1). Potential risk factor for the acute coronary syndromes
Eur. Heart J., July 2, 2001; 22(14): 1226 - 1234.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. D. Blann and G. Y. H. Lip
Editorial: Cell Adhesion Molecules in Cardiovascular Disease and Its Risk Factors--What Can Soluble Levels Tell Us?
J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 1745 - 1747.
[Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Roque, J. T. Fallon, J. J. Badimon, W. X. Zhang, M. B. Taubman, and E. D. Reis
Mouse Model of Femoral Artery Denudation Injury Associated With the Rapid Accumulation of Adhesion Molecules on the Luminal Surface and Recruitment of Neutrophils
Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 335 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Braun, P. Pietsch, K. Schror, G. Baumann, and S. B. Felix
Cellular adhesion molecules on vascular smooth muscle cells
Cardiovasc Res, February 1, 1999; 41(2): 395 - 401.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
A. D BLANN and G. Y H LIP
Cell adhesion molecules in cardiovascular disease: what can soluble levels tell us?
Heart, January 1, 1999; 81(1): 101 - 102.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.