Skip Navigation

Cardiovascular Research 1997 35(3):414-421; doi:10.1016/S0008-6363(97)00169-7
© 1997 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wang, X.
Right arrow Articles by Feuerstein, G. Z
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, X.
Right arrow Articles by Feuerstein, G. Z
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1997, European Society of Cardiology

The use of mRNA differential display for discovery of novel therapeutic targets in cardiovascular disease

Xinkang Wang and Giora Z Feuerstein*

Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA

* Corresponding author. Dept. of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406, USA. Tel.: +1 (610) 270-6802; fax: +1 (610) 270-4114; e-mail: Giora_Z_Feuerstein@SBPHRD.COM@INET

Recent advances in molecular biology techniques have provided powerful tools for discovery of novel genes relevant to both biological and pathological processes. mRNA differential display is an emerging technique for novel gene discovery and it has been successfully applied to many physiological and pathological conditions including normal development, cell differentiation, cancer, cardiovascular disease, inflammation and CNS disorders. In the present work, we briefly illustrate the critical procedure and highlight most recent technical improvements and modifications of this technology. Based upon the successful applications of this technique in cardiovascular research, it may provide a valuable and powerful investigational tool for the identification of novel therapeutic targets in cardiovascular diseases.

KEYWORDS Cardiovascular disease; Differential display; Gene expression; Therapeutic target


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 EndocrinologyHome page
R. R. Miles, J. P. Sluka, D. L. Halladay, R. F. Santerre, L. V. Hale, L. Bloem, K. Thirunavukkarasu, R. J. S. Galvin, J. M. Hock, and J. E. Onyia
ADAMTS-1: A Cellular Disintegrin and Metalloprotease with Thrombospondin Motifs Is a Target for Parathyroid Hormone in Bone
Endocrinology, December 1, 2000; 141(12): 4533 - 4542.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
J. Sturtevant
Applications of Differential-Display Reverse Transcription-PCR to Molecular Pathogenesis and Medical Mycology
Clin. Microbiol. Rev., July 1, 2000; 13(3): 408 - 427.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. R. Miles, J. P. Sluka, R. F. Santerre, L. V. Hale, L. Bloem, G. Boguslawski, K. Thirunavukkarasu, J. M. Hock, and J. E. Onyia
Dynamic Regulation of RGS2 in Bone: Potential New Insights into Parathyroid Hormone Signaling Mechanisms
Endocrinology, January 1, 2000; 141(1): 28 - 36.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
B. B. NGIMBOUS, F. BOURGEOIS, C. MAS, M. SIMONNEAU, and J.-M. MOALIC
Heart transplantation changes the expression of distinct gene families
Physiol Genomics, December 21, 2001; 7(2): 115 - 126.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.