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Cardiovascular Research 1997 35(2):217-222; doi:10.1016/S0008-6363(97)00085-0
© 1997 by European Society of Cardiology
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Copyright © 1997, European Society of Cardiology

Contribution of hypoxia to the development of cardiomyopathy in hamsters

Yoshiyuki Watanabe, Hideo Kusuoka*, Kazuki Fukuchi, Toshiyuki Fujiwara and Tsunehiko Nishimura1

Division of Tracer Kinetics, Biomedical Research Center, Osaka University Medical School, 2-2 Yamadaoka Suita, Osaka 565, Japan

* Corresponding author. Tel.: +81 (6) 879-3461; fax: +81 (6) 879-3469; e-mail: kusuoka@tracer.med.osaka-u.ac.jp

Objective: It has been hypothesized that microvascular spasms cause cardiomyopathy. To elucidate the contribution of hypoxia to the development of cardiomyopathy, the newly-developed hypoxia tracer, Tc-99m nitroimidazole, was applied to detect myocardial hypoxia in a hamster model. Methods: Tc-99m nitroimidazole (180 MBq) and I-125 iodoantipyrine (370 kBq) were injected into cardiomyopathic Syrian hamsters or control hamsters at age 10, 25, and 40 weeks (n = 6 in each group). The myocardial uptake of Tc-99m nitroimidazole was measured and dual tracer autoradiography was performed. Results: Histologic study revealed that the cardiomyopathic hamsters at age 10, 25 and 40 weeks were in the myocytolytic stage, the fibrotic and healing stage, and the hypertrophy and dilatation stage, respectively. Tc-99m nitroimidazole uptake was significantly greater in the cardiomyopathic hamsters than in the controls at age 25 weeks (cardiomyopathic hamsters, 33.3±4.7% g dose/g; control, 25.2±3.1), whereas there were no significant differences between both strains at age 10 and 40 weeks. The quantified concentration of I-125 iodoantipyrine in the cardiomyopathic hamster at age 40 weeks was significantly lower than that in the controls. When the Tc-99m nitroimidazole uptake was normalized by I-125 iodoantipyrine concentrations, the cardiomyopathic hamsters at age 25 and 40 weeks showed significantly greater uptake than the controls. Conclusion: The myocardium in cardiomyopathic hamsters was hypoxic at the fibrotic and healing stage and may be hypoxic at the hypertrophy and dilatation stage. This may contribute to the development of cardiomyopathy.

KEYWORDS Cardiomyopathy; Nitroimidazole; Hypoxia; Microcirculation; Hamster; Syrian hamster

1 Address for reprints: Tsunehiko Nishimura, MD, PhD, Division of Tracer Kinetics, Biomedical Research Center, Osaka University Medical School, 2-2 Yamadaoka Suita, Osaka 565, Japan. Tel.: +81 (6) 879-3460; fax: +81 (6) 879-3469.


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