© 1997 by European Society of Cardiology
Copyright © 1997, European Society of Cardiology
Sympathetic modulation of hypoxic pulmonary vasoconstriction in intact dogs
Laboratory of Cardiovascular and Respiratory Physiology, Free University of Brussels, Brussels, Belgium
* Corresponding author. Department of Intensive Care, Erasmus University Hospital, Lennik Road 808, B-1070 Brussels, Belgium. Tel.: +32 (2) 555.44.10; fax: +32 (2) 555.46.98.
Background: The effects of the sympathetic nervous system on hypoxic pulmonary vasoconstriction (HPV) have been reported variably. We studied the effects of adrenergic receptor blockade and epidural blockade on HPV in 32 pentobarbital-anaesthetised intact dogs. Methods: Pulmonary arterial flow–pressure relationships were determined in hyperoxia and hypoxia, at baseline and after 
-blockade (phentolamine 2 mg/kg + 50 µg·kg–1·h–1), β-blockade (propranolol 2 mg/kg), β-blockade, epidural blockade (lignocaine 20 mg/kg), and β- plus epidural blockade. Results: At reference flow of 3.5 l·min–1·m–2, the mean hypoxic response (hypoxia-induced increase in transpulmonary pressure gradient, each n=8) changed from 6.0±0.9 to 3.5±1.0 mmHg after -blockade, from 5.8±0.9 to 7.3±0.7 mmHg after β-blockade, from 4.1±0.8 to 9.0±1.4 mmHg after β-blockade, and from 3.4±1.0 to 4.3±0.9 mmHg after epidural blockade (all P<0.05), and was not affected by epidural blockade after β-blockade. Conclusions: In pentobarbital-anaesthetised dogs, (1) HPV is attenuated by - and enhanced by β-, β- and epidural blockade, and (2) epidural blockade has no significant adrenergic-unrelated effect on the pulmonary vasculature.
KEYWORDS Dog, anesthetized; Pulmonary circulation; Hypoxia; Flow–pressure relationships; Autonomic nervous system; Adrenergic receptors
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