© 1997 by European Society of Cardiology
Copyright © 1997, European Society of Cardiology
von Willebrand factor: a marker of endothelial dysfunction in vascular disorders?
Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
* Corresponding author. Tel: +44 (121) 554 3801; Fax: +44 (121) 554 4083.
The vascular endothelium is involved in the production of many important substances which are involved in cardiovascular pathophysiology. One such substance which is synthesised by, and stored in, endothelial cells is von Willebrand factor (vWf). When released, vWf appears to mediate platelet aggregation and adhesion. Numerous clinical and experimental reports suggest that high vWf levels reflect damage to the endothelium or endothelial dysfunction. The close association between vWf and the processes of thrombus formation (thrombogenesis) or atherogenesis also suggests that high vWf levels may be a useful indirect indicator of atherosclerosis and/or thrombosis. The availability of a useful marker of endothelial dysfunction may have potential clinical value. The measurement of such a marker can perhaps be a non-invasive way of assisting in clinical diagnosis or as an indicator of disease progression. High vWf levels have also been shown to have prognostic value in patients with ischaemic heart disease, peripheral vascular disease and inflammatory vascular disease. However, there is limited information that increased vWf is actually causal in the progression of vascular disease and that measures aimed at reducing vWf levels will be beneficial. In addition, interpretation of raised plasma vWf levels is complicated by the fact that vWf may be an acute phase reactant. Further research is indicated to explore the predictive value of this marker in population studies and, perhaps, therapeutic approaches in (and the value of) modulating vWf levels or function.
KEYWORDS von Willebrand factor (vWf); Thrombogenesis; Atherogenesis; Endothelium
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. M. Kucharska-Newton, D. J. Couper, J. S. Pankow, R. J. Prineas, T. D. Rea, N. Sotoodehnia, A. Chakravarti, A. R. Folsom, D. S. Siscovick, and W. D. Rosamond Hemostasis, Inflammation, and Fatal and Nonfatal Coronary Heart Disease: Long-Term Follow-Up of the Atherosclerosis Risk in Communities (ARIC) Cohort Arterioscler Thromb Vasc Biol, December 1, 2009; 29(12): 2182 - 2190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Kalyoncu, O. Dizdar, A. Erkan Duman, O. Karadag, A. Tufan, O. Yucel, O. Tayfur, D. Sen, Z. Ulger, A. Kepez, et al. Alterations of von Willebrand Factor and Ristocetin Cofactor Activity During Atrial Fibrillation Clinical and Applied Thrombosis/Hemostasis, February 1, 2009; 15(1): 103 - 108. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Cambronero, F. Marin, V. Roldan, D. Hernandez-Romero, M. Valdes, and G. Y.H. Lip Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis Eur. Heart J., January 9, 2009; (2009) ehn538v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Frankel, J. B. Meigs, J. M. Massaro, P. W.F. Wilson, C. J. O'Donnell, R. B. D'Agostino, and G. H. Tofler Von Willebrand Factor, Type 2 Diabetes Mellitus, and Risk of Cardiovascular Disease: The Framingham Offspring Study Circulation, December 9, 2008; 118(24): 2533 - 2539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Spiel, J. C. Gilbert, and B. Jilma Von Willebrand Factor in Cardiovascular Disease: Focus on Acute Coronary Syndromes Circulation, March 18, 2008; 117(11): 1449 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gomez-Ambrosi, V. Catalan, B. Ramirez, A. Rodriguez, I. Colina, C. Silva, F. Rotellar, C. Mugueta, M. J. Gil, J. A. Cienfuegos, et al. Plasma Osteopontin Levels and Expression in Adipose Tissue Are Increased in Obesity J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3719 - 3727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Homoncik, A. Gessl, A. Ferlitsch, B. Jilma, and H. Vierhapper Altered Platelet Plug Formation in Hyperthyroidism and Hypothyroidism J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3006 - 3012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Heilmann, W. Rath, and K. Pollow Hemostatic Abnormalities in Patients With Severe Preeclampsia Clinical and Applied Thrombosis/Hemostasis, July 1, 2007; 13(3): 285 - 291. [Abstract] [PDF]
|
|
|
|
 |
|
 G. I Varughese, J. V Patel, J. Tomson, and G. Y H Lip Effects of blood pressure on the prothrombotic risk in 1235 patients with non-valvular atrial fibrillation Heart, April 1, 2007; 93(4): 495 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-i. Inoue, H. Takano, M. Sakurai, T. Oda, H. Tamura, R. Yanagisawa, A. Shimada, and T. Yoshikawa Pulmonary exposure to diesel exhaust particles enhances coagulatory disturbance with endothelial damage and systemic inflammation related to lung inflammation. Experimental Biology and Medicine, November 1, 2006; 231(10): 1626 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. O. Ogunshola, V. Djonov, R. Staudt, J. Vogel, and M. Gassmann Chronic excessive erythrocytosis induces endothelial activation and damage in mouse brain Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R678 - R684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nuver, A. J. Smit, J. van der Meer, M. P. van den Berg, W. T.A. van der Graaf, M. T. Meinardi, D. Th. Sleijfer, H. J. Hoekstra, A. I. van Gessel, A. M. van Roon, et al. Acute Chemotherapy-Induced Cardiovascular Changes in Patients With Testicular Cancer J. Clin. Oncol., December 20, 2005; 23(36): 9130 - 9137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Antoniades, D. Tousoulis, C. Vasiliadou, C. Pitsavos, C. Chrysochoou, D. Panagiotakos, C. Tentolouris, K. Marinou, N. Koumallos, and C. Stefanadis Genetic Polymorphism on Endothelial Nitric Oxide Synthase Affects Endothelial Activation and Inflammatory Response During the Acute Phase of Myocardial Infarction J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1101 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Farkas, J. Nemcsik, E. Kolossvary, Z. Jarai, E. Nadory, C. Farsang, and I. Kiss Impairment of skin microvascular reactivity in hypertension and uraemia Nephrol. Dial. Transplant., September 1, 2005; 20(9): 1821 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Oechslin, W. Kiowski, R. Schindler, A. Bernheim, B. Julius, and H. P. Brunner-La Rocca Systemic Endothelial Dysfunction in Adults With Cyanotic Congenital Heart Disease Circulation, August 23, 2005; 112(8): 1106 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Y H Lip, L A Pearce, B S P Chin, D S G Conway, and R G Hart Effects of congestive heart failure on plasma von Willebrand factor and soluble P-selectin concentrations in patients with non-valvar atrial fibrillation Heart, June 1, 2005; 91(6): 759 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Arikan and S. Sen Endothelial Damage and Hemostatic Markers in Patients with Uncomplicated Mild-to-Moderate Hypertension and Relationship with Risk Factors Clinical and Applied Thrombosis/Hemostasis, April 1, 2005; 11(2): 147 - 159. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Swampillai, S. Doshi, A. G Fraser, J. Goodfellow, and C. J. Jones Review: Clinical assessment of endothelial function -- an update The British Journal of Diabetes & Vascular Disease, March 1, 2005; 5(2): 72 - 76. [Abstract] [PDF]
|
|
|
|
 |
|
 L. B. Ware, M. D. Eisner, B. T. Thompson, P. E. Parsons, and M. A. Matthay Significance of Von Willebrand Factor in Septic and Nonseptic Patients with Acute Lung Injury Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 766 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Frossard, I. Fuchs, J. M. Leitner, K. Hsieh, M. Vlcek, H. Losert, H. Domanovits, W. Schreiber, A. N. Laggner, and B. Jilma Platelet Function Predicts Myocardial Damage in Patients With Acute Myocardial Infarction Circulation, September 14, 2004; 110(11): 1392 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Sutton, H. E. Mang, S. B. Campos, R. M. Sandoval, M. C. Yoder, and B. A. Molitoris Injury of the renal microvascular endothelium alters barrier function after ischemia Am J Physiol Renal Physiol, August 1, 2003; 285(2): F191 - F198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-Y. Chong, A.D. Blann, and G.Y.H. Lip Assessment of endothelial damage and dysfunction: observations in relation to heart failure QJM, April 1, 2003; 96(4): 253 - 267. [Full Text] [PDF]
|
|
|
|
|
|
N.A.Y. Chung, C. Lydakis, F. Belgore, A.D. Blann, and G.Y.H. Lip Angiogenesis in myocardial infarction. An acute or chronic process? Eur. Heart J., October 2, 2002; 23(20): 1604 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G.C. Spencer, D. Gurney, A. D. Blann, D. G. Beevers, and G. Y.H. Lip Von Willebrand Factor, Soluble P-Selectin, and Target Organ Damage in Hypertension: A Substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Hypertension, July 1, 2002; 40(1): 61 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Suzuki, S. Sakamoto, K. Maniwa, A. Saitoh, Y. Hirayama, H. Kobayashi, and T. Matsuo Fatal Pulmonary Arterial Thrombosis Associated With Chlorine Gas Poisoning Clinical and Applied Thrombosis/Hemostasis, October 1, 2001; 7(4): 356 - 358. [Abstract] [PDF]
|
|
|
|
|
|
P. Clausen, J. S. Jensen, G. Jensen, K. Borch-Johnsen, and B. Feldt-Rasmussen Elevated Urinary Albumin Excretion Is Associated With Impaired Arterial Dilatory Capacity in Clinically Healthy Subjects Circulation, April 10, 2001; 103(14): 1869 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Calles-Escandon and M. Cipolla Diabetes and Endothelial Dysfunction: A Clinical Perspective Endocr. Rev., February 1, 2001; 22(1): 36 - 52. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. L. Lip, F. Belgore, A. D. Blann, M. W. Hope-Ross, J. M. Gibson, and G. Y. H. Lip Plasma VEGF and Soluble VEGF Receptor FLT-1 in Proliferative Retinopathy: Relationship to Endothelial Dysfunction and Laser Treatment Invest. Ophthalmol. Vis. Sci., July 1, 2000; 41(8): 2115 - 2119. [Abstract] [Full Text]
|
|
|
|
|
|
I R A GOLDSMITH, A D BLANN, R L PATEL, and G Y H LIP Plasma fibrinogen, soluble P-selectin, and von Willebrand factor in aortic valve disease: evidence for abnormal haemorheology, platelet activation, and endothelial dysfunction Heart, May 1, 2000; 83(5): 577 - 578. [Full Text]
|
|
|
|
|
|
G. Y. H. Lip and A. D. Blann Does Hypertension Confer a Prothrombotic State? : Virchow’s Triad Revisited Circulation, January 25, 2000; 101(3): 218 - 220. [Full Text] [PDF]
|
|
|
|
|
|
G. R. Y. De Meyer, M. F. Hoylaerts, M. M. Kockx, H. Yamamoto, A. G. Herman, and H. Bult Intimal Deposition of Functional von Willebrand Factor in Atherogenesis Arterioscler Thromb Vasc Biol, October 1, 1999; 19(10): 2524 - 2534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Di Carli, D. Bianco-Batlles, M. E. Landa, A. Kazmers, H. Groehn, O. Muzik, and G. Grunberger Effects of Autonomic Neuropathy on Coronary Blood Flow in Patients With Diabetes Mellitus Circulation, August 24, 1999; 100(8): 813 - 819. [Abstract] [Full Text] [PDF]
|
|