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Cardiovascular Research 1997 34(1):41-47; doi:10.1016/S0008-6363(97)00010-2
© 1997 by European Society of Cardiology
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Copyright © 1997, European Society of Cardiology

Regulation of intracellular Ca2+ in the heart during diabetes

Grant N Piercea,* and James C Russellb

aInstitute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre and the Department of Physiology, University of Manitoba, Winnipeg, MB, Canada
bDepartment of Surgery, University of Alberta, Edmonton, Alta., Canada

* Corresponding author. Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, 351 Tache Ave., Winnipeg, MB, Canada R2H 2A6. Tel. +1 204 235-3414; Fax +1 204 233-6723; E-mail: pierce@sbrc.umanitoba.ca

Cardiovascular disease is a significant medical problem. The diabetic population is even more susceptible to cardiovascular complications and heart failure than non-diabetic patients. Atherosclerotic complications, a neuropathy and microvascular lesions have all been implicated causally in the accelerated cardiovascular disease during diabetes. However, one mechanism which may participate in the abnormalities in heart performance demonstrated during diabetes and may also contribute to heart failure in the diabetic is a derangement in the capacity of the myocardial cell to regulate its [Ca2+]. The purpose of this treatise is to identify the current controversies and conclusions available regarding the specific defects in Ca2+ flux thought to contribute to these cardiac defects during diabetes mellitus.

KEYWORDS Diabetes; Calcium, intracellular concentration; Cardiomyopathy; Calcium fluxes; Contractile function


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