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Cardiovascular Research 1996 31(1):148-151; doi:10.1016/S0008-6363(95)00185-9
© 1996 by European Society of Cardiology
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Copyright © 1996, European Society of Cardiology

Pre-conditioning with adenosine leads to concentration-dependent infarct size reduction in the isolated rabbit heart

R.G. Woolfson*, V.C. Patel and D.M. Yellon

The Hatter Institute for Cardiovascular Studies, Department of Academic Cardiology, University College London Medical School, Gower Street, London WC1E 6AU, UK

* Corresponding author. Tel. (+44-171) 380-9888; Fax (+44-171) 388-5095.

Adenosine (ADO) has a cardioprotective effect in ischemia-reperfusion injury when administered both prior to ischemia and during reperfusion. ADO has also been implicated in the mechanism of ischemic pre-conditioning. The aim of this study was to investigate whether there was a concentration-response between the administration of ADO prior to ischemia-reperfusion and reduction in subsequent infarct size. Rabbit isolated perfused hearts were subjected to 45 min ischemia and 180 min reperfusion following pre-treatment with either Krebs Henseleit buffer alone or buffer containing ADO at a range of concentrations (3 µM–100 µM) for 5 min followed by 5 min perfusion with buffer. Infarct/risk ratios were significantly reduced in hearts pre-perfused with higher (>3 µM) concentrations of ADO (Control, 58.5 ± 1.5%; 3 µM ADO, 51.6 ± 3.0%; 6 µM ADO, 44.1 ± 2.0%; 10 µM ADO, 33.3 ± 1.9%; 20 µM ADO, 26.6 ± 0.9%; 50 µM ADO, 21.6 ± 3.5%; 100 µM ADO, 23.0 ± 0.6%). We conclude that pre-treatment with ADO leads to a concentration-dependent reduction in infarct size.

KEYWORDS Adenosine; Myocardial infarct size; Rabbit, heart


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