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Cardiovascular Research 1995 30(6):1028-1032; doi:10.1016/S0008-6363(95)00181-6
© 1995 by European Society of Cardiology
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Copyright © 1995, European Society of Cardiology

Platelet-activating factor (PAF) does not affect diastolic function in isolated rat hearts

H.R. Muñoz*, R.D. Evans, S.C.U. Marsch and P. Foëx

Nuffield Department of Anaesthetics, The Radcliffe Infirmary, Oxford OX2 6HE, UK

* Corresponding author. Fax (+44-1895) 65 794191.

Platelet-activating factor might be responsible for the alterations of diastolic function observed in different disease states and these potential effects have not been studied. The effect of incremental concentrations of platelet-activating factor (to a maximum of 200 nM) was therefore examined in isolated perfused rat heart. Platelet-activating factor decreased coronary flow rate and contractility in a dose-dependent manner. Although high-dose platelet-activating factor decreased peak dP/dt compared to baseline, this was not significant when compared to vehicle-administered control. There were no changes in the time constant of left ventricular relaxation and the chamber stiffness constant. These results do not support a major direct role of platelet-activating factor in diastolic dysfunction.

KEYWORDS Platelet-activating factor; Diastolic function; Rat; heart


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