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Cardiovascular Research 1995 30(5):763-768; doi:10.1016/S0008-6363(95)00116-6
© 1995 by European Society of Cardiology
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Copyright © 1995, European Society of Cardiology

Reperfusion hastens appearance and extent of distribution of type I collagen in infarct zone: immunohistochemical study in rat experimental infarction

Satoshi Yamasaki, Shozo Kusachi*, Hiroki Moritani, Jyun Kondo, Satoshi Hirohata, Akiko Tamura and Takao Tsuji

The First Department of Internal Medicine, Okayama University Medical School, 2-5-1, Shikata-cho, Okayama 700, Japan

* Corresponding author. Tel.: (+ 81-86) 223-7151, ext. 2414; fax (+ 81-86)252-5991.

Background: The effects of reperfusion on time-dependent alteration of type I collagen have not been examined. Objectives: We compared the sequential changes in the appearance and distribution of type I collagen in reperfused infarct rat hearts to those in non-reperfused hearts. Methods: Using an experimental rat model of infarction, we performed immunohistochemical staining with a polyclonal antibody to type I collagen by the avidin-biotin-peroxidase method. Reperfusion was established after 2-h coronary ligation that produced complete necrosis of myocytes. Results: In reperfused hearts, type I collagen appeared in the peripheral zone of the infarct at day 2, which was 1 day earlier than in non-reperfused hearts. The extent of distribution of type I collagen in reperfused hearts was comparable to that observed approximately 1 day later in non-reperfused hearts. Conclusion: Reperfusion can accelerate collagen matrix formation compared with that in non-reperfused hearts after acute myocardial infarction.

KEYWORDS Reperfusion; Extracellular matrix; Myocardial fibrosis; Avidin-biotin-peroxidase method; Myocardial infarct healing; Rat, anesthetized


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