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Cardiovascular Research 1995 30(4):511-517; doi:10.1016/S0008-6363(95)00088-7
© 1995 by European Society of Cardiology
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Copyright © 1995, European Society of Cardiology

Angiotensin II signal transduction and the mitogen-activated protein kinase pathway

Jennifer L. Duffa, c, Mario B. Marrerob, William G. Paxtonb, Bernhard Schiefferb, Kenneth E. Bernsteina, b and Bradford C. Berk*

aDepartment of Biochemistry, Emory University, Atlanta, GA, USA
bDepartment of Pathology, Emory University, Atlanta, GA, USA
cDepartment of Medicine, Cardiology Division, University of Washington, Seattle, WA, USA

* Corresponding author. Tel. (206) 685-6960; Fax (206) 616-1580.

In this review, the angiotensin-II-mediated signal transduction pathways involved in vascular smooth muscle cell growth are discussed. Classical pathways involving phospholipase C and protein kinase C, as well as the mitogen-activated protein kinase pathway, are common signal transduction pathways activated by a variety of growth factors to stimulate cell growth. Besides its vasoconstrictor activity, angiotensin II stimulates hypertrophy of vascular smooth muscle cells and is involved in neointimal proliferation following balloon angioplasty. Understanding angiotensin-II-stimulated signaling events, as well as the crosstalk among signaling pathways, may form the basis for the development of new therapies for hypertension and restenosis.

KEYWORDS Angiotensin II; MAP kinase; Vascular smooth muscle; Hypertrophy; Signal transduction; Protein kinase C


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