© 1995 by European Society of Cardiology
Copyright © 1995, European Society of Cardiology
Assessment of right ventricular contractile state with the conductance catheter technique in the pig
aDepartment of Anesthesiology College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
bDepartment of Surgery College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
cDivision of Circulatory Physiology College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
* Correspondence to Dr Dickstein.
Objective: Since the conductance catheter method has facilitated evaluation of left ventricular contractile state in both laboratory and clinical studies, the aim of this study was to determine whether the technique is similarly useful for the right ventricle. Methods: A series of right ventricular pressure-volume loops was obtained in seven open chest pigs during transient vena caval occlusion using a 12-electrode conductance catheter. End systolic pressure-volume relationships, stroke work-end diastolic volume relationships, and 
-end diastolic volume relationships were compared at control and during infusion of dobutamine and esmolol. Results: Right ventricular pressure-volume loops generated with the conductance catheter were of a shape consistent with those previously reported by other volume measurement techniques, and responded to changes in inotropic state in a predictable fashion. Dobutamine shifted the three contractile relationships leftward, whereas esmolol shifted them rightward. Comparisons of stroke volume derived with the conductance catheter and with a pulmonary artery flow probe demonstrated the ability of the conductance technique to measure relative volume changes. Conclusions: The conductance catheter provides a continuous measure of right ventricular volume that was used to detect changes in right ventricular contractile state in pigs. This represents a promising and much needed method for the evaluation of right ventricular function.
KEYWORDS contractility; right heart; contracility measurements; ventricular performance; volume
This work was supported in part by an NIH R01 award HL48109-03.
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