© 1993 by European Society of Cardiology
Copyright © 1993, European Society of Cardiology
Direct evidence that coronary perfusion affects diastolic myocardial mechanical properties in canine heart
The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, Maryland 21205, USA – Cardiology Division of Department of Medicine: J R Resar, H R Halperin, R G Weiss, F C P Yin; Department of Biomedical Engineering: R M Judd; NMR Division of Department of Radiology: V P Chacko.
Correspondence to Dr Yin.
Objective: The effect of coronary perfusion on left ventricular chamber distensibility is only indirect evidence that perfusion alters the mechanical properties of the myocardium. The aim of this study was to demonstrate explicitly the effects of coronary perfusion on these mechanical properties. Methods: The effects of different levels of coronary perfusion were studied both on in-plane stress-strain relations and on transverse stiffness in an isolated, perfused canine interventricular septal preparation. Additionally, to determine the vascular compartment responsible for the mechanical effects of perfusion on tissue properties, we examined the in-plane stress-strain responses and transverse stiffness after embolisation of the vasculature with 15 µm microspheres. Results: The data show a clear dependence of tissue stress-strain properties on perfusion. The in-plane stress-strain relations were shifted to the left and transverse stiffness increased linearly as septal artery perfusion pressure increased. The dependence of both the in-plane stress-strain relations and transverse stiffness on perfusion was significantly decreased following embolisation. Conclusions: Myocardial tissue stiffness is directly related to perfusion. The linear relationship between transverse stiffness and perfusion makes it easier to assess the effects of perfusion on tissue stiffness than with in-plane stress-strain relations. Perfusion of capillaries and/or venules is largely responsible for these alterations in myocardial stiffness.
Cardiovascular Research 1993;27:403-410
KEYWORDS coronary perfusion; stress-strain; stiffness; myocardial tissue properties
The authors gratefully acknowledge the technical assistance of John Downs, Kristi Pier, and Donna McCready. This work was supported in part by National Heart, Lung, and Blood Institute Grants RO1-HL44092 and RO1-HL33621, an Established Investigatorship to H H, American Heart Association with funds contributed by the Maryland Affiliate, and a Clinician Scientist to RGW from the American Heart Association.
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