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Cardiovascular Research 1990 24(5):352-357; doi:10.1093/cvr/24.5.352
© 1990 by European Society of Cardiology
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Copyright © 1990, European Society of Cardiology

Atrial natriuretic peptides in canine hypoxic pulmonary vasoconstriction

Jean-Luc Vachiery, Philippe Lejeune, Roger Hallemans, Serge Brimioulle, Marie-France Debiève, Maurice Abramow and Robert Naeije

Laboratory of Physiology and Pathophysiology, Faculty of Medicine, Erasmus Campus, Free University of Brussels, Belgium

Study objective – The aim of the study was to investigate whether atrial natriuretic peptides have a physiological role in regulation of the pulmonary circulation.

Design – Plasma concentrations of immunoreative atrial natriuretic peptide and guanosine-3',5'-cyclic monophosphate (cGMP) were measured during evaluation of pulmonary vascular tone by multipoint pulmonary arterial pressure-cardiac index (Ppa/Q) relationships.

Subjects – Experimental animals were 17 mongrel dogs of either sex, 21-35 kg weight, anaesthetised with pentobarbitone.

Measurements and main results – Measurements of Ppa/Q relationships and atrial natriuretic peptide/cGMP were made during hyperoxia (FiO2 0.4) and hypoxia (FiO2 0.1). Hypoxic pulmonary vasoconstriction, defined as hypoxia induced increase in pulmonary artery pressure over the entire range of Q studied from 2-5 litre·min–1·m–2, was elicited in nine dogs ("responders"). In the other eight dogs, hypoxia did not change pulmonary artery pressure over the entire range of Q studied ("non-responders"). At neither the highest nor the lowest Q in hyperoxia did atrial natriuretic peptide and cGMP concentrations differ between these two groups, nor did acute reduction in Q affect the concentrations in either group. At the highest Q, plasma atrial natriuretic peptide increased in hypoxia from 11(SEM 2) to 15(3) pmol·litre–1 in the responders (p<0.05), and from 15(2) to 20(2) pmol·litre–1 in the non-responders (p<0.05). However at the lowest Q, atrial natriuretic peptide was increased in non-responders only, from 17(3) to 23(4) pmol·litre–1 (p<0.05). CGMP did not vary significantly in any experimental condition.

Conclusions – Hypoxia slightly increased plasma atrial natriuretic peptides without any relationship with associated pulmonary haemodynamic changes. These data do not support the hypothesis that atrial natriuretic peptides play a physiological role in the regulation of the pulmonary circulation in dogs.

KEYWORDS atrial natriuretic peptides; hypoxic pulmonary vasoconstriction; pulmonary arterial pressure flow relationships

Correspondence to: Dr Vachiery, at Department of Intensive Care, Erasme University Hospital, 808 route de Lennik, B-1070 Brussels, Belgium


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