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Cardiovascular Research 1987 21(10):766-771; doi:10.1093/cvr/21.10.766
© 1987 by European Society of Cardiology
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Copyright © 1987, European Society of Cardiology

Effects of nifedipine on coronary reactive and exercise induced hyperaemia

ROBERT J BACHE, DEBORAH QUANBECK, DAVID C HOMANS and XUE-ZHENG DAI

From the Division of Cardiology, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA

The effects of nifedipine on coronary vasodilatation were studied during reactive hyperaemia after a transient coronary occlusion and during active hyperaemia associated with graded treadmill exercise. Studies were performed in 10 chronically instrumented dogs in which left circumflex coronary artery flow was measured with an electromagnetic flowmeter and myocardial oxygen extraction was determined from indwelling aortic and coronary sinus catheters. Thirty minutes after administration of nifedipine (10 µg·kg–1 iv), when coronary blood flow, arterial pressure, and heart rate had returned to control values, the vasodilatation following a 10 s coronary occlusion was significantly blunted, so that reactive hyperaemia blood flow debt repayment (mean(SEM)) was reduced from 387(39)% during control conditions to 270(33)% after nifedipine (p<0.05). In contrast, nifedipine did not alter the coronary vasodilatation that occurred in response to graded treadmill exercise so that the increase in coronary blood flow during exercise was not different from the control response. Thus, although nifedipine blunted ischaemic coronary vasodilatation during reactive hyperaemia, it did not alter coronary vasodilatation during active hyperaemia resulting from physiological increases of myocardial oxygen consumption.

KEYWORDS reactive hyperaemia; exercise; coronary blood flow; nifedipine

Address for correspondence and reprints: Dr Robert J Bache, Cardiovascular Division, Box 338 Mayo Building, University of Minnesota, Minneapolis, MN 55455 USA.


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