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Cardiovascular Research 1985 19(12):793-799; doi:10.1093/cvr/19.12.793
© 1985 by European Society of Cardiology
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Copyright © 1985, European Society of Cardiology

Size and shape of enzymatically isolated ventricular myocytes from rats and cardiomyopathic hamsters

ALBERT L SORENSON, DAVID TEPPER, EDMUND H SONNENBLICK, THOMAS F ROBINSON and JOSEPH M CAPASSO*

From the Cardiovascular Research Center, Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, New York

* Address for correspondence and reprint requests: Joseph M Capasso, Ph.D., Cardiovascular Research Center, Forchheimer Building - Room G 42, Albert Einstein College of Medicine, 1300 Moms Park Avenue, Bronx, New York 10461, USA.

Rod-shaped and branched ventricular myocytes from rats and cardiomyopathic hamsters (strain 53.58) were isolated enzymatically, and their widths and lengths were measured in physiological salt solutions containing normal levels of calcium (2.5 mmol). In rats of approximately 200 g body weight, the average myocyte width and length are 25µm and 115µm. The isolated cells are also classified according to shape with nearly 50% branched or otherwise irregular. Myocytes of the hearts of the 53.58 strain of cardiomyopathic hamsters at 7 months of age are significantly larger than control hamsters of the same age, indicating that cellular hypertrophy has occurred. Estimates of the number of cells in the ventricles indicate that there is a cell loss of nearly 13% in the myopathic heart. A consideration of the significance of wider and longer myocytes with undiminished myofibrillar mass lead to the conclusion that the decreased contractility displayed by the cardiomyopathic hamster heart must be due, at least in part, to functional defects in the myofibrillar apparatus, in the system of activation, or in cellular integration.

KEYWORDS cardiomyopathic hamster; isolated cells; cell loss; cell size; cell volume


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