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Cardiovascular Research 1981 15(11):659-667; doi:10.1093/cvr/15.11.659
© 1981 by European Society of Cardiology
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Copyright © 1981, European Society of Cardiology

Inosine as a selective inotropic agent on ischaemic myocardium?

KEITH V WOOLLARD*, ROSALIE O KINGABY{dagger}, MAX J LAB, ARTHUR W G COLE{ddagger} and T NORMAN PALMER

From the Departments of Physiology and Biochemistry, Charing Cross Hospital Medical School. London

* Present Address: Dr K V Woollard. Royal Perth Hospital. Perth. Australia.

{dagger} Author to whom correspondence and reprint requests should be addressed at Department of Physiology. Charing Cross Hospital Medical School. Fulham Palace Road. London W6 8RF UK.

{ddagger} Present Address: Dr A W G Cole. Pharmacia Fine Chemicals' AB. Box 175. S-751 04 Uppsala I. Sweden.

Intravenous infusion of inosine (15 mg·kg–1.min–1) to the open-chested pig resulted in hypotension, coronary vasodilatation and slightly increased myocardial contractility. Following coronary occlusion, the action of inosine to increase myocardial contractility was apparently selective. Regional myocardial performance of ischaemic myocardium was increased significantly relative to nonischaemic. The selectivity of inotropic action was not mimicked by glucose-insulin-potassium. It is concluded that the selectivity is multifactoral and that the inotropic, vasodilatory and metabolic actions of the nucleoside contribute to the apparent selectivity.


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