Skip Navigation

Cardiovascular Research 1967 1(4):362-370; doi:10.1093/cvr/1.4.362
© 1967 by European Society of Cardiology
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Newland, H.
Right arrow Articles by Nordöy, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Newland, H.
Right arrow Articles by Nordöy, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1967, European Society of Cardiology

Effect of Large Doses of Warfarin Sodium on Haemostasis and on ADP-induced Platelet Aggregation in vivo in the Rat

A Survey of Experimental Thrombosis and Coumarin Anticoagulant Therapy*

Hillery Newland and Arne Nordöy

From the Department of Pathology, Medical College of Georgia, Eugene Talmadge Memorial Hospital, Augusta, Georgia, U.S.A.

Authors' Synopsis: Large doses of warfarin that induced prothrombin levels considered unsafe for man significantly reduced ADP aggregation of platelets in vivo in the rat. The effectiveness of the platelet plug in haemostasis was also severely impaired. The possible mechanisms for this effect are discussed. A survey of the literature of the effect of coumarin therapy on experimental thrombosis is given.

* Supported by United States Public Health Service Research Grant HE-03973, USPHS Graduate Training Grant in Pathology 2G-207, J. L. Tiedemanns Tobaksfabrik- J. H. Andresens Medicinske Fond and Aktieselskabet Freia Chocholade Fabricks Medicinske Fond.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.