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Cardiovascular Research 1967 1(4):335-340; doi:10.1093/cvr/1.4.335
© 1967 by European Society of Cardiology
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Copyright © 1967, European Society of Cardiology

Effect of Transient Resistance Changes on Atrial Septal Defects and Other Intracardiac Shunts*

R. M. McCredie{dagger}

From the Hallstrom Institute of Cardiology, Royal Prince Alfred Hospital, Camperdown, N.S.W., Australia

{dagger} Present address for reprints: The Prince Henry Hospital, Little Bay, N.S.W., Australia.

Author's Synopsis: The variability of the estimated left to right shunt, using a nitrous oxide method, was assessed in 22 patients with intracardiac defects. With both spontaneous and drug-induced changes in resistance there was a correlation between the changes in the ratio of pulmonary to systemic blood flow and the relative resistance. It appears that the relative resistance to outflow from the two ventricles is an important determinant of the flow ratio.

* Work done during tenure of a Senior Research Fellowship of the National Heart Foundation of Australia.


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