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Cardiovascular Research 1967 1(3):255-262; doi:10.1093/cvr/1.3.255
© 1967 by European Society of Cardiology
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Copyright © 1967, European Society of Cardiology

Effects of Angiotensin on the Heart and Coronary Circulation of the Dog Before and After Beta-adrenergic Blockade*

Gordon Ross

From the Department of Physiology, UCLA, School of Medicine Los Angeles, California, U.S.A.

Author's Synopsis: Rapid intravenous injections of angiotensin increased systemic pressure and reduced coronary flow while cardiac output remained unchanged or reduced. After a few seconds cardiac output and coronary flow increased. After β-adrenergic blockade, angiotensin produced only a reduction in cardiac output and the coronary flow increase per unit rise of pressure was diminished. These studies provide further evidence indicating an intimate association between angiotensin and the sympathetico-adrenal axis.

* Supported by a grant from the Los Angeles County Heart Association.


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