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Cardiovascular Research 1967 1(3):219-228; doi:10.1093/cvr/1.3.219
© 1967 by European Society of Cardiology
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Copyright © 1967, European Society of Cardiology

Myocardial Oxygen Consumption, Left Ventricular Fibre Shortening and Wall Tension*

Roger R. Taylor{dagger}, Horacio E. Cingolani{ddagger}, Thomas P. Graham and Richard L. Clancy

From the Laboratory of Cardiovascular Physiology, National Heart Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.

{dagger} Participated in this study during tenure of Research Fellowship of the National Heart Foundation of Australia.

{ddagger} Participated in this study during tenure of National Institutes of Health International Postdoctoral Fellow.

Authors' Synopsis: Myocardial oxygen consumption (MVO2) was studied in a canine right heart bypass preparation. At constant heart rate and left ventricular peak developed tension (calculated from ventricular volume and pressure), doubling cardiac inflow increased MVO2 by 1·3 ml./100 g LV/min. This approximate 10% increase is attributed to increased contractile element shortening and work.

* Presented in part before the Federation of American Societies for Experimental Biology, April 15, 1966 (Fed. Proc.) 1966, 25, 644).


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