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Cardiovascular Research 1967 1(1):80-90; doi:10.1093/cvr/1.1.80
© 1967 by European Society of Cardiology
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Copyright © 1967, European Society of Cardiology

Central and Peripheral Cardiovascular Changes Following Chemical Stimulation of the Surface of the Dog's Heart*

D. H. Bergel and G. S. Makin

From the Medical Research Council Cardiovascular Research Unit, Postgraduate Medical School. London

Authors' Synopsis: Epicardial stimulation of the left ventricle with nicotine in open-chest anaesthetized dogs produced a vagally mediated reflex fall in heart rate and blood pressure. In addition, reflex increase in femoral arterial blood flow was due to cholinergic sympathetic activation to skeletal muscle vessels. Epicardial stimulation also produced reflex depression of left ventricular force. The epicardial chemoreflex was inactivated by prior intracoronary injection of veratrine.

* This work was supported by the Medical Research Council and the Tobacco Manufacturers' Association.


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