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Cardiovascular Research 1967 1(1):63-66; doi:10.1093/cvr/1.1.63
© 1967 by European Society of Cardiology
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Copyright © 1967, European Society of Cardiology

Inhibition of Adenosine-induced Coronary Vasodilatation*

Winifred G. Nayler, Jocelyn M. Price and T. E. Lowe

From Baker Medical Research Institute, Commercial Road, Prahran S.1, Victoria, Australia

Authors' Synopsis: Isolated spontaneously beating rat and guinea-pig hearts were used to investigate the direct dilator action of adenosine (5 µg./ml.) on the coronary vasculature. Phenoxybenzamine (10 µg./ml.) blocked the coronary dilator effect of adenosine and of another coronary dilator drug, dipyridamole, but failed to block adenosine-induced bradycardia. These results are interpreted to mean that adrenergic receptors may be involved in the coronary-dilator effect of adenosine.

* This work was done during the tenure of a grant-in-aid from the National Heart Foundation of Australia.


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