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Cardiovascular Research 1967 1(1):34-41; doi:10.1093/cvr/1.1.34
© 1967 by European Society of Cardiology
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Copyright © 1967, European Society of Cardiology

Effect of Propranolol on Arrhythmias following Coronary Artery Occlusion in Dogs

R. G. Shanks and D. Dunlop

From Imperial Chemical Industries Limited, Pharmaceuticals Division, Research Department, Alderley Park, Macclesfield, Cheshire

Authors' Synopsis: Electrocardiograms were obtained from conscious dogs before and on the four days after acute ligation of a branch of the left coronary artery. The intravenous injection of propranolol did not abolish the arrhythmias present 24 hr. after ligation, but reduced or abolished the exaggerated ectopic response to adrenaline on the second to fourth days after ligation. This effect resulted from blockade of adrenergic β-receptors in the myocardium.


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